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@ARTICLE{Lucio:839920,
      author       = {Lucio, David and Martínez-Ohárriz, María Cristina and
                      Jaras, Gonzalo and Aranaz, Paula and González-Navarro,
                      Carlos J. and Radulescu, Aurel and Irache, Juan M.},
      title        = {{O}ptimization and evaluation of zein nanoparticles to
                      improve the oral delivery of glibenclamide. {I}n vivo study
                      using {C}. elegans},
      journal      = {European journal of pharmaceutics and biopharmaceutics},
      volume       = {121},
      issn         = {0939-6411},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2017-07498},
      pages        = {104 - 112},
      year         = {2017},
      abstract     = {The aim of this work was to evaluate the capability of zein
                      nanoparticles as oral carriers for glibenclamide (GB).
                      Nanoparticles were prepared by a desolvation procedure in
                      the presence of lysine as stabilizer. A central composite
                      design was used to optimize this preparative process. Under
                      the selected conditions, nanoparticles displayed a size of
                      about 190 nm, a surface charge of −37 mV and a payload of
                      45 µg GB/mg. Small-angle neutron scattering and X-ray
                      diffraction techniques suggested an internal fractal-like
                      structure, based on the repetition of spherical blocks of
                      zein units (about 20 nm) grouped to form the nanoparticles.
                      This structure, stabilized by lysine molecules located at
                      the surface, would determine the release of GB (molecularly
                      trapped into the nanoparticles) by a pure diffusion
                      mechanism. Moreover, GB-loaded nanoparticles induced a
                      significant hypolipidemic effect with a reduction of about
                      $15\%$ in the fat content of C. elegans worms. In addition,
                      did not induce any significant modification in the lifespan
                      of worms. In summary, the employment of zein nanoparticles
                      as delivery systems of glibenclamide may be an interesting
                      approach to develop new oral formulations of this
                      antidiabetic drug.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
                      / 6G15 - FRM II / MLZ (POF3-6G15)},
      pid          = {G:(DE-HGF)POF3-6G4 / G:(DE-HGF)POF3-6G15},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28986295},
      UT           = {WOS:000414621100011},
      doi          = {10.1016/j.ejpb.2017.09.018},
      url          = {https://juser.fz-juelich.de/record/839920},
}