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@ARTICLE{Zaloga:839948,
      author       = {Zaloga, Jan and Feoktystov, Artem and Garamus, Vasil M. and
                      Karawacka, Weronika and Ioffe, Alexander and Brückel,
                      Thomas and Tietze, Rainer and Alexiou, Christoph and Lyer,
                      Stefan},
      title        = {{S}tudies on the adsorption and desorption of mitoxantrone
                      to lauric acid/albumin coated iron oxide nanoparticles},
      journal      = {Colloids and surfaces / B},
      volume       = {161},
      issn         = {0927-7765},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2017-07525},
      pages        = {18 - 26},
      year         = {2018},
      abstract     = {A rational use of superparamagnetic iron oxide
                      nanoparticles (SPIONs) in drug delivery, diagnostics, and
                      other biomedical applications requires deep understanding of
                      the molecular drug adsorption/desorption mechanisms for
                      proper design of new pharmaceutical formulations. The
                      adsorption and desorption of the cytostatic Mitoxantrone
                      (MTO) to lauric acid-albumin hybrid coated particles SPIONs
                      (SEONLA−HSA) was studied by Fourier transform infrared
                      spectroscopy (FTIR), dynamic light scattering (DLS), surface
                      titration, release experiments and small-angle neutron and
                      X-ray scattering. Such MTO-loaded nanoparticles have shown
                      very promising results in in vivo animal models before,
                      while the exact binding mechanism of the drug was unknown.
                      SEONLA−HSA formulations have shown better stability under
                      drug loading in comparison with uncoated nanoparticle and
                      sustainable drug release to compare with protein solution.
                      Adsorption of MTO to SEONLA−HSA leads to decreasing of
                      absolute value of zeta potential and repulsive interaction
                      among particles, which points to the location of separate
                      molecules of MTO on the outer surface of LA-HSA shell.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / JCNS-2 / PGI-4},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-2-20110106 / I:(DE-Juel1)PGI-4-20110106},
      pnm          = {6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
                      Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)KWS1-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000423636100003},
      doi          = {10.1016/j.colsurfb.2017.09.057},
      url          = {https://juser.fz-juelich.de/record/839948},
}