Home > Publications database > Studies on the adsorption and desorption of mitoxantrone to lauric acid/albumin coated iron oxide nanoparticles > print

001     839948
005     20250129094207.0
024 7 _ |a 10.1016/j.colsurfb.2017.09.057
|2 doi
024 7 _ |a 0927-7765
|2 ISSN
024 7 _ |a 1873-4367
|2 ISSN
024 7 _ |a 2128/16121
|2 Handle
024 7 _ |a WOS:000423636100003
|2 WOS
037 _ _ |a FZJ-2017-07525
082 _ _ |a 540
100 1 _ |a Zaloga, Jan
|0 P:(DE-HGF)0
|b 0
245 _ _ |a Studies on the adsorption and desorption of mitoxantrone to lauric acid/albumin coated iron oxide nanoparticles
260 _ _ |a Amsterdam [u.a.]
|c 2018
|b Elsevier Science
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1512475185_31847
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a A rational use of superparamagnetic iron oxide nanoparticles (SPIONs) in drug delivery, diagnostics, and other biomedical applications requires deep understanding of the molecular drug adsorption/desorption mechanisms for proper design of new pharmaceutical formulations. The adsorption and desorption of the cytostatic Mitoxantrone (MTO) to lauric acid-albumin hybrid coated particles SPIONs (SEONLA−HSA) was studied by Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), surface titration, release experiments and small-angle neutron and X-ray scattering. Such MTO-loaded nanoparticles have shown very promising results in in vivo animal models before, while the exact binding mechanism of the drug was unknown. SEONLA−HSA formulations have shown better stability under drug loading in comparison with uncoated nanoparticle and sustainable drug release to compare with protein solution. Adsorption of MTO to SEONLA−HSA leads to decreasing of absolute value of zeta potential and repulsive interaction among particles, which points to the location of separate molecules of MTO on the outer surface of LA-HSA shell.
536 _ _ |0 G:(DE-HGF)POF3-6G15
|f POF III
|x 0
|c POF3-6G15
|a 6G15 - FRM II / MLZ (POF3-6G15)
536 _ _ |a 6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
|0 G:(DE-HGF)POF3-6G4
|c POF3-623
|f POF III
|x 1
588 _ _ |a Dataset connected to CrossRef
650 2 7 |a Medicine
|0 V:(DE-MLZ)SciArea-190
|2 V:(DE-HGF)
|x 0
650 1 7 |a Health and Life
|0 V:(DE-MLZ)GC-130-2016
|2 V:(DE-HGF)
|x 0
693 _ _ |a Forschungs-Neutronenquelle Heinz Maier-Leibnitz
|e KWS-1: Small angle scattering diffractometer
|f NL3b
|1 EXP:(DE-MLZ)FRMII-20140101
|0 EXP:(DE-MLZ)KWS1-20140101
|5 EXP:(DE-MLZ)KWS1-20140101
|6 EXP:(DE-MLZ)NL3b-20140101
|x 0
700 1 _ |a Feoktystov, Artem
|0 P:(DE-Juel1)144382
|b 1
|u fzj
700 1 _ |a Garamus, Vasil M.
|0 P:(DE-HGF)0
|b 2
700 1 _ |a Karawacka, Weronika
|0 P:(DE-HGF)0
|b 3
700 1 _ |a Ioffe, Alexander
|0 P:(DE-Juel1)130729
|b 4
|u fzj
700 1 _ |a Brückel, Thomas
|0 P:(DE-Juel1)130572
|b 5
|u fzj
700 1 _ |a Tietze, Rainer
|0 P:(DE-HGF)0
|b 6
700 1 _ |a Alexiou, Christoph
|0 P:(DE-HGF)0
|b 7
|e Corresponding author
700 1 _ |a Lyer, Stefan
|0 P:(DE-HGF)0
|b 8
773 _ _ |a 10.1016/j.colsurfb.2017.09.057
|g Vol. 161, p. 18 - 26
|0 PERI:(DE-600)1500523-9
|p 18 - 26
|t Colloids and surfaces / B
|v 161
|y 2018
|x 0927-7765
856 4 _ |u https://juser.fz-juelich.de/record/839948/files/1-s2.0-S0927776517306355-main.pdf
|y Restricted
856 4 _ |y Published on 2017-09-27. Available in OpenAccess from 2019-09-27.
|u https://juser.fz-juelich.de/record/839948/files/accepted_version.pdf
856 4 _ |y Published on 2017-09-27. Available in OpenAccess from 2019-09-27.
|x icon
|u https://juser.fz-juelich.de/record/839948/files/accepted_version.gif?subformat=icon
856 4 _ |y Published on 2017-09-27. Available in OpenAccess from 2019-09-27.
|x icon-1440
|u https://juser.fz-juelich.de/record/839948/files/accepted_version.jpg?subformat=icon-1440
856 4 _ |y Published on 2017-09-27. Available in OpenAccess from 2019-09-27.
|x icon-180
|u https://juser.fz-juelich.de/record/839948/files/accepted_version.jpg?subformat=icon-180
856 4 _ |y Published on 2017-09-27. Available in OpenAccess from 2019-09-27.
|x icon-640
|u https://juser.fz-juelich.de/record/839948/files/accepted_version.jpg?subformat=icon-640
856 4 _ |y Published on 2017-09-27. Available in OpenAccess from 2019-09-27.
|x pdfa
|u https://juser.fz-juelich.de/record/839948/files/accepted_version.pdf?subformat=pdfa
856 4 _ |x icon
|u https://juser.fz-juelich.de/record/839948/files/1-s2.0-S0927776517306355-main.gif?subformat=icon
|y Restricted
856 4 _ |x icon-1440
|u https://juser.fz-juelich.de/record/839948/files/1-s2.0-S0927776517306355-main.jpg?subformat=icon-1440
|y Restricted
856 4 _ |x icon-180
|u https://juser.fz-juelich.de/record/839948/files/1-s2.0-S0927776517306355-main.jpg?subformat=icon-180
|y Restricted
856 4 _ |x icon-640
|u https://juser.fz-juelich.de/record/839948/files/1-s2.0-S0927776517306355-main.jpg?subformat=icon-640
|y Restricted
856 4 _ |x pdfa
|u https://juser.fz-juelich.de/record/839948/files/1-s2.0-S0927776517306355-main.pdf?subformat=pdfa
|y Restricted
909 C O |o oai:juser.fz-juelich.de:839948
|p openaire
|p VDB:MLZ
|p driver
|p open_access
|p VDB
|p dnbdelivery
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 1
|6 P:(DE-Juel1)144382
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 4
|6 P:(DE-Juel1)130729
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 5
|6 P:(DE-Juel1)130572
913 1 _ |a DE-HGF
|9 G:(DE-HGF)POF3-6G15
|x 0
|4 G:(DE-HGF)POF
|v FRM II / MLZ
|1 G:(DE-HGF)POF3-6G0
|0 G:(DE-HGF)POF3-6G15
|3 G:(DE-HGF)POF3
|2 G:(DE-HGF)POF3-600
|b Forschungsbereich Materie
|l Großgeräte: Materie
913 1 _ |a DE-HGF
|b Forschungsbereich Materie
|l Von Materie zu Materialien und Leben
|1 G:(DE-HGF)POF3-620
|0 G:(DE-HGF)POF3-623
|2 G:(DE-HGF)POF3-600
|v Facility topic: Neutrons for Research on Condensed Matter
|9 G:(DE-HGF)POF3-6G4
|x 1
|4 G:(DE-HGF)POF
|3 G:(DE-HGF)POF3
914 1 _ |y 2018
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
915 _ _ |a Embargoed OpenAccess
|0 StatID:(DE-HGF)0530
|2 StatID
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b COLLOID SURFACE B : 2015
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
915 _ _ |a WoS
|0 StatID:(DE-HGF)0110
|2 StatID
|b Science Citation Index
915 _ _ |a WoS
|0 StatID:(DE-HGF)0111
|2 StatID
|b Science Citation Index Expanded
915 _ _ |a IF < 5
|0 StatID:(DE-HGF)9900
|2 StatID
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0310
|2 StatID
|b NCBI Molecular Biology Database
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Thomson Reuters Master Journal List
920 _ _ |l yes
920 1 _ |0 I:(DE-Juel1)JCNS-FRM-II-20110218
|k JCNS (München) ; Jülich Centre for Neutron Science JCNS (München) ; JCNS-FRM-II
|l JCNS-FRM-II
|x 0
920 1 _ |0 I:(DE-Juel1)JCNS-2-20110106
|k JCNS-2
|l Streumethoden
|x 1
920 1 _ |0 I:(DE-Juel1)PGI-4-20110106
|k PGI-4
|l Streumethoden
|x 2
980 1 _ |a FullTexts
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-Juel1)JCNS-FRM-II-20110218
980 _ _ |a I:(DE-Juel1)JCNS-2-20110106
980 _ _ |a I:(DE-Juel1)PGI-4-20110106
981 _ _ |a I:(DE-Juel1)JCNS-2-20110106

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21