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@ARTICLE{Zepf:840067,
      author       = {Zepf, Florian D. and Bubenzer-Busch, Sarah and Runions,
                      Kevin C. and Rao, Pradeep and Wong, Janice W. Y. and
                      Mahfouda, Simone and Morandini, Hugo A. E. and Stewart,
                      Richard M. and Moore, Julia K. and Biskup, Caroline S. and
                      Eickhoff, Simon and Fink, Gereon Rudolf and Langner, Robert},
      title        = {{F}unctional connectivity of the vigilant-attention network
                      in children and adolescents with
                      attention-deficit/hyperactivity disorder},
      journal      = {Brain and cognition},
      volume       = {131},
      issn         = {0278-2626},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2017-07631},
      pages        = {56-65},
      year         = {2019},
      abstract     = {The ability to maintain attention to simple tasks (i.e.,
                      vigilant attention, VA) is often impaired in
                      attention-deficit/hyperactivity disorder (ADHD), but the
                      underlying pathophysiological mechanisms at the brain
                      network level are not clear yet. We therefore investigated
                      ADHD-related differences in resting-state functional
                      connectivity within a meta-analytically defined brain
                      network of 14 distinct regions subserving VA (comprising 91
                      connections in total), as well as the association of
                      connectivity with markers of behavioural dysfunction in 17
                      children (age range: 9–14 years) with a diagnosis of
                      ADHD and 21 age-matched neurotypical controls. Our analyses
                      revealed selective, rather than global, differences in the
                      intrinsic coupling between nodes of the VA-related brain
                      network in children with ADHD, relative to controls. In
                      particular, ADHD patients showed substantially diminished
                      intrinsic coupling for 7 connections and increased coupling
                      for 4 connections, with many differences involving
                      connectivity with the anterior insula. Moreover,
                      connectivity strength of several aberrant connections was
                      found to be associated with core aspects of ADHD
                      symptomatology, such as poor attention, difficulties with
                      social functioning, and impaired cognitive control,
                      attesting to the behavioural relevance of specific
                      connectivity differences observed in the resting state.},
      cin          = {INM-1 / INM-3 / INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-3-20090406 /
                      I:(DE-Juel1)INM-7-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29150311},
      UT           = {WOS:000462806500007},
      doi          = {10.1016/j.bandc.2017.10.005},
      url          = {https://juser.fz-juelich.de/record/840067},
}