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@ARTICLE{Wensing:840129,
author = {Wensing, Tobias and Cieslik, Edna and Müller, Veronika and
Hoffstaedter, Felix and Eickhoff, Simon and Nickl-Jockschat,
Thomas},
title = {{N}eural correlates of formal thought disorder: {A}n
activation likelihood estimation meta-analysis.},
journal = {Human brain mapping},
volume = {38},
number = {10},
issn = {1065-9471},
address = {New York, NY},
publisher = {Wiley-Liss},
reportid = {FZJ-2017-07689},
pages = {4946–4965},
year = {2017},
abstract = {Formal thought disorder (FTD) refers to a
psychopathological dimension characterized by disorganized
and incoherent speech. Whether symptoms of FTD arise from
aberrant processing in language-related regions or more
general cognitive networks, however, remains debated. Here,
we addressed this question by a quantitative meta-analysis
of published functional neuroimaging studies on FTD. The
revised Activation Likelihood Estimation (ALE) algorithm was
used to test for convergent aberrant activation changes in
18 studies (30 experiments) investigating FTD, of which 17
studies comprised schizophrenia patients and one study
healthy subjects administered to S-ketamine. Additionally,
we analyzed task-dependent and task-independent
(resting-state) functional connectivity (FC) of brain
regions showing convergence in activation changes.
Subsequent functional characterization was performed for the
initial clusters and the delineated connectivity networks by
reference to the BrainMap database. Consistent activation
changes were found in the left superior temporal gyrus (STG)
and two regions within the left posterior middle temporal
gyrus (p-MTG), ventrally (vp-MTG) and dorsally (dp-MTG).
Functional characterization revealed a prominent functional
association of ensuing clusters from our ALE meta-analysis
with language and speech processing, as well as auditory
perception in STG and with social cognition in dp-MTG. FC
analysis identified task-dependent and task-independent
networks for all three seed regions, which were mainly
related to language and speech processing, but showed
additional involvement in higher order cognitive functions.
Our findings suggest that FTD is mainly characterized by
abnormal activation in brain regions of the left hemisphere
that are associated with language and speech processing, but
also extend to higher order cognitive functions. Hum Brain
Mapp 38:4946-4965, 2017. © 2017 Wiley Periodicals, Inc.},
cin = {INM-7 / INM-1},
ddc = {610},
cid = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-1-20090406},
pnm = {574 - Theory, modelling and simulation (POF3-574) / SMHB -
Supercomputing and Modelling for the Human Brain
(HGF-SMHB-2013-2017) / HBP SGA1 - Human Brain Project
Specific Grant Agreement 1 (720270)},
pid = {G:(DE-HGF)POF3-574 / G:(DE-Juel1)HGF-SMHB-2013-2017 /
G:(EU-Grant)720270},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:28653797},
pmc = {pmc:PMC5685170},
UT = {WOS:000417002000011},
doi = {10.1002/hbm.23706},
url = {https://juser.fz-juelich.de/record/840129},
}