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@ARTICLE{Pool:840458,
      author       = {Pool, Eva-Maria and Leimbach, Martha and Binder, Ellen and
                      Nettekoven, Charlotte and Eickhoff, Simon and Fink, Gereon
                      R. and Grefkes, Christian},
      title        = {{N}etwork dynamics engaged in the modulation of motor
                      behavior in stroke patients},
      journal      = {Human brain mapping},
      volume       = {39},
      number       = {3},
      issn         = {1065-9471},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2017-07974},
      pages        = {1078–1092},
      year         = {2018},
      abstract     = {Stroke patients with motor deficits typically feature
                      enhanced neural activity in several cortical areas when
                      moving their affected hand. However, also healthy subjects
                      may show higher levels of neural activity in tasks with
                      higher motor demands. Therefore, the question arises to what
                      extent stroke-related overactivity reflects
                      performance-level-associated recruitment of neural resources
                      rather than stroke-induced neural reorganization. We here
                      investigated which areas in the lesioned brain enable the
                      flexible adaption to varying motor demands compared to
                      healthy subjects. Accordingly, eleven well-recovered
                      left-hemispheric chronic stroke patients were scanned using
                      functional magnetic resonance imaging. Motor system activity
                      was assessed for fist closures at increasing movement
                      frequencies performed with the affected/right or
                      unaffected/left hand. In patients, an increasing movement
                      rate of the affected hand was associated with stronger
                      neural activity in ipsilesional/left primary motor cortex
                      (M1) but unlike in healthy controls also in
                      contralesional/right dorsolateral premotor cortex (PMd) and
                      contralesional/right superior parietal lobule (SPL).
                      Connectivity analyses using dynamic causal modeling revealed
                      stronger coupling of right SPL onto affected/left M1 in
                      patients but not in controls when moving the affected/right
                      hand independent of the movement speed. Furthermore,
                      coupling of right SPL was positively coupled with the
                      “active” ipsilesional/left M1 when stroke patients moved
                      their affected/right hand with increasing movement
                      frequency. In summary, these findings are compatible with a
                      supportive role of right SPL with respect to motor function
                      of the paretic hand in the reorganized brain.},
      cin          = {INM-3 / INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-7-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29193484},
      UT           = {WOS:000424804400002},
      doi          = {10.1002/hbm.23872},
      url          = {https://juser.fz-juelich.de/record/840458},
}