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@ARTICLE{Eichner:840625,
      author       = {Eichner, Adina and Stahlberg, Sören and Sonnenberger,
                      Stefan and Lange, Stefan and Dobner, Bodo and Ostermann,
                      Andreas and Schrader, Tobias E. and Hauß, Thomas and
                      Schroeter, Annett and Huster, Daniel and Neubert, Reinhard
                      H. H.},
      title        = {{I}nfluence of the penetration enhancer isopropyl myristate
                      on stratum corneum lipid model membranes revealed by neutron
                      diffraction and 2 {H} {NMR} experiments},
      journal      = {Biochimica et biophysica acta / Biomembranes},
      volume       = {1859},
      number       = {5},
      issn         = {0005-2736},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {FZJ-2017-08130},
      pages        = {745 - 755},
      year         = {2017},
      abstract     = {The stratum corneum (SC) provides the main barrier
                      properties in native skin. The barrier function is
                      attributed to the intercellular lipids, forming continuous
                      multilamellar membranes. In this study, SC lipid membranes
                      in model ratios were enriched with deuterated lipids in
                      order to investigate structural and dynamical properties by
                      neutron diffraction and 2H solid-state NMR spectroscopy.
                      Further, the effect of the penetration enhancer isopropyl
                      myristate (IPM) on the structure of a well-known SC lipid
                      model membrane containing synthetically derived
                      methyl-branched ceramide [EOS], ceramide [AP], behenic acid
                      and cholesterol (23/10/33/33 $wt\%)$ was investigated. IPM
                      supported the formation of a single short-periodicity phase
                      (SPP), in which we determined the molecular organization of
                      CER[AP] and CER[EOS]-br for the first time. Furthermore, the
                      thermotropic phase behavior of the lipid system was analyzed
                      by additional neutron diffraction studies as well as by 2H
                      solid-state NMR spectroscopy, covering temperatures of 32
                      °C (physiological skin temperature), 50 °C, and 70 °C
                      with a subsequent cooldown back to skin temperature. Both
                      techniques revealed a phase transition and a hysteresis
                      effect. During the cooldown, Bragg peaks corresponding to a
                      long-periodicity phase (LPP) appeared. Additionally, 2H NMR
                      revealed that the IPM molecules are isotopic mobile at all
                      temperatures.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
                      Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)BIODIFF-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28132900},
      UT           = {WOS:000398870800010},
      doi          = {10.1016/j.bbamem.2017.01.029},
      url          = {https://juser.fz-juelich.de/record/840625},
}