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@ARTICLE{Yokoyama:840627,
      author       = {Yokoyama, Takeshi and Ostermann, Andreas and Schrader,
                      Tobias E. and Mizuguchi, Mineyuki},
      title        = {{L}arge-scale crystallization and neutron crystallographic
                      analysis of {HSP}70 in complex with {ADP}},
      journal      = {Acta crystallographica / F},
      volume       = {73},
      number       = {10},
      issn         = {2053-230X},
      address      = {Oxford [u.a.]},
      publisher    = {Blackwell},
      reportid     = {FZJ-2017-08132},
      pages        = {555 - 559},
      year         = {2017},
      abstract     = {HSP70 belongs to the heat-shock protein family and binds to
                      unfolded proteins,driven by ATP hydrolysis, in order to
                      prevent aggregation. Previous X-raycrystallographic analyses
                      of HSP70 have shown that HSP70 binds to ADP withinternal
                      water molecules. In order to elucidate the role of the water
                      molecules,including their H/D atoms, a neutron diffraction
                      study of the human HSP70ATPase domain was initiated.
                      Deuterated large crystals of the HSP–ADPcomplex (1.2–1.8
                      mm3) were successfully grown by large-scale
                      crystallization,and a neutron diffraction experiment at
                      BIODIFF resulted in diffraction to amaximum resolution of
                      2.2 A ˚ . After data reduction, the overall
                      completeness,Rmeas and average I/(I) were $90.4\%,$ $11.7\%$
                      and 8.1, respectively, indicating thatthe data set was
                      sufficient to visualize H and D atoms.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      ddc          = {530},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
                      Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)BIODIFF-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28994403},
      UT           = {WOS:000412683100003},
      doi          = {10.1107/S2053230X1701264X},
      url          = {https://juser.fz-juelich.de/record/840627},
}