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@ARTICLE{Lichtenstein:841199,
      author       = {Lichtenstein, Thorsten and Sprenger, Alina and Weiss,
                      Kilian and Slebocki, Karin and Cervantes, Barbara and
                      Karampinos, Dimitrios and Maintz, David and Fink, Gereon R.
                      and Henning, Tobias D. and Lehmann, Helmar C.},
      title        = {{MRI} biomarkers of proximal nerve injury in {CIDP}},
      journal      = {Annals of Clinical and Translational Neurology},
      volume       = {5},
      number       = {1},
      issn         = {2328-9503},
      address      = {Chichester [u.a.]},
      publisher    = {Wiley},
      reportid     = {FZJ-2017-08292},
      pages        = {19–28},
      year         = {2018},
      abstract     = {ObjectiveTo evaluate the utility of nerve diffusion tensor
                      imaging (DTI), nerve cross-sectional area, and muscle
                      magnetic resonance imaging (MRI) multiecho Dixon for
                      assessing proximal nerve injury in chronic inflammatory
                      demyelinating polyneuropathy (CIDP).MethodsIn this
                      prospective observational cohort study, 11 patients with
                      CIDP and 11 healthy controls underwent a multiparametric MRI
                      protocol with DTI of the sciatic nerve and assessment of
                      muscle proton-density fat fraction of the biceps femoris and
                      the quadriceps femoris muscles by multiecho Dixon MRI.
                      Patients were longitudinally evaluated by MRI, clinical
                      examination, and nerve conduction studies at baseline and
                      after 6 months.ResultsIn sciatic nerves of CIDP patients,
                      mean cross-sectional area was significantly higher and
                      fractional anisotropy value was significantly lower,
                      compared to controls. In contrast, muscle proton-density fat
                      fraction was significantly higher in thigh muscles of
                      patients with CIDP, compared to controls. MRI parameters
                      showed high reproducibility at baseline and 6
                      months.InterpretationAdvanced MRI parameters demonstrate
                      subclinical proximal nerve damage and intramuscular fat
                      accumulation in CIDP. Data suggest DTI and multiecho Dixon
                      MRI might be useful in estimating axonal damage and
                      neurogenic muscle changes in CIDP.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29376089},
      UT           = {WOS:000422664400003},
      doi          = {10.1002/acn3.502},
      url          = {https://juser.fz-juelich.de/record/841199},
}