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@INPROCEEDINGS{Unverricht:841279,
      author       = {Unverricht, Marcus and Busch, Nicole and Kriehuber, Ralf},
      title        = {{HIGH} {EXPRESSION} {LEVELS} {OF} {SURVIVIN} {PROTEIN}
                      {DOES} {NOT} {ABOLISH} {UV}-{INDUCED} {APOPTOSIS} {IN}
                      {SCL}-{II} {CELLS}},
      reportid     = {FZJ-2017-08371},
      year         = {2008},
      abstract     = {Survivin is a member of the inhibitors of apoptosis and has
                      been implicated in both the regulation of cell division and
                      the suppression of apoptosis. Whereas over-expression of
                      survivin correlates with an unfavourable prognosis in many
                      malignant tumours, siRNA against survivin causes a reduction
                      of cell proliferation, the induction of apoptosis and an
                      enhanced radiosensitivity of squamous cell carcinoma cell
                      lines and other tumour cell lines. The apoptotic response
                      and the survivin protein expression levels in the squamous
                      cell carcinoma derived SCL-II cell line were analyzed after
                      exposure to ionizing radiation (IR) and UV radiation.
                      Apoptosis was assessed by PARP cleavage and by flow
                      cytometry (Annexin V-FITC/ PI assay). SCL-II showed a low
                      induction of apoptosis after exposure to IR but a strong
                      apoptotic response after exposure to UV $(25\%$ apoptotic
                      cells 5 h after UV), which correlated with PARP cleavage and
                      characteristic changes in cell morphology like membrane
                      blebbing and formation of apoptotic bodies. Cell cycle
                      analysis revealed that exposure to UV, but not IR, induced a
                      G1 checkpoint arrest in SCL-II cells.There was no change in
                      survivin protein expression after exposure to IR and UV
                      compared to controls. One of the used survivin antibodies
                      detected a subband (28 kDa) which correlated with the
                      apoptotic state of SCL-II cells.Conclusions: Survivin
                      expression does not interfere with apoptosis induction in
                      SCL-II cells. UV triggeres apoptosis in SCL-II cells is not
                      abolished by a high expression level of survivin. Apoptosis
                      in SCL-II cells seems to be associated with cell cycle
                      perturbations.},
      month         = {Oct},
      date          = {2008-10-06},
      organization  = {11th Annual Meeting of the German
                       Society for Biological Radiation
                       Research, Tübingen (Germany), 6 Oct
                       2008 - 8 Oct 2008},
      subtyp        = {After Call},
      cin          = {S-US},
      cid          = {I:(DE-Juel1)S-US-20090406},
      pnm          = {899 - ohne Topic (POF3-899)},
      pid          = {G:(DE-HGF)POF3-899},
      typ          = {PUB:(DE-HGF)6},
      url          = {https://juser.fz-juelich.de/record/841279},
}