TY  - JOUR
AU  - Ortega, Jose Antonio
AU  - Riccardi, Laura
AU  - Minniti, Elirosa
AU  - Borgogno, Marco
AU  - Arencibia, Jose M.
AU  - Greco, Maria L.
AU  - Minarini, Anna
AU  - Sissi, Claudia
AU  - De Vivo, Marco
TI  - Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity
JO  - Journal of medicinal chemistry
VL  - 61
IS  - 3
SN  - 1520-4804
CY  - Washington, DC
PB  - ACS
M1  - FZJ-2017-08380
SP  - 1375-1379
PY  - 2018
AB  - We used a pharmacophore hybridization strategy to combine key structural elements of merbarone and etoposide and generated new type II topoisomerase (topoII) poisons. This first set of hybrid topoII poisons shows promising antiproliferative activity on human cancer cells, endorsing their further exploration for anticancer drug discovery.
LB  - PUB:(DE-HGF)16
C6  - pmid:29077404
UR  - <Go to ISI:>//WOS:000425063400051
DO  - DOI:10.1021/acs.jmedchem.7b01388
UR  - https://juser.fz-juelich.de/record/841289
ER  -