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@ARTICLE{Ortega:841289,
      author       = {Ortega, Jose Antonio and Riccardi, Laura and Minniti,
                      Elirosa and Borgogno, Marco and Arencibia, Jose M. and
                      Greco, Maria L. and Minarini, Anna and Sissi, Claudia and De
                      Vivo, Marco},
      title        = {{P}harmacophore {H}ybridization {T}o {D}iscover {N}ovel
                      {T}opoisomerase {II} {P}oisons with {P}romising
                      {A}ntiproliferative {A}ctivity},
      journal      = {Journal of medicinal chemistry},
      volume       = {61},
      number       = {3},
      issn         = {1520-4804},
      address      = {Washington, DC},
      publisher    = {ACS},
      reportid     = {FZJ-2017-08380},
      pages        = {1375-1379},
      year         = {2018},
      abstract     = {We used a pharmacophore hybridization strategy to combine
                      key structural elements of merbarone and etoposide and
                      generated new type II topoisomerase (topoII) poisons. This
                      first set of hybrid topoII poisons shows promising
                      antiproliferative activity on human cancer cells, endorsing
                      their further exploration for anticancer drug discovery.},
      cin          = {IAS-5 / INM-9},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IAS-5-20120330 / I:(DE-Juel1)INM-9-20140121},
      pnm          = {574 - Theory, modelling and simulation (POF3-574)},
      pid          = {G:(DE-HGF)POF3-574},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29077404},
      UT           = {WOS:000425063400051},
      doi          = {10.1021/acs.jmedchem.7b01388},
      url          = {https://juser.fz-juelich.de/record/841289},
}