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| Hauptseite > Publikationsdatenbank > Increased micronucleus induction in 170Tm-irradiated nanogold-labeled SCL II-cells > print |
| Hauptseite > Publikationsdatenbank > Increased micronucleus induction in 170Tm-irradiated nanogold-labeled SCL II-cells > print |
| 001 | 841531 | ||
| 005 | 20210129232030.0 | ||
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| 037 | _ | _ | |a FZJ-2017-08575 |
| 041 | _ | _ | |a English |
| 100 | 1 | _ | |a Kriehuber, Ralf |0 P:(DE-Juel1)133469 |b 0 |e Corresponding author |u fzj |
| 111 | 2 | _ | |a 36th Annual Meeting of the European Radiation Research Society |g ERRS |c Tours |d 2008-09-01 - 2008-09-04 |w France |
| 245 | _ | _ | |a Increased micronucleus induction in 170Tm-irradiated nanogold-labeled SCL II-cells |
| 260 | _ | _ | |c 2008 |
| 336 | 7 | _ | |a Conference Paper |0 33 |2 EndNote |
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| 520 | _ | _ | |a Photoelectric absorption of photons with energies slightly above the K shell binding energy of an appropriate element can result in the emission of a shower of low-energy Auger-electrons. It is well known that those electrons released by Auger-electron-emitting radionuclides located in the immediate vicinity of the DNA cause high-LET-type damage and induce an enhanced relative biological effectiveness when compared to low-LET radiation. Therefore, an enhanced biological effectiveness is expected after photon activation as well. To proof if photoelectric absorption leads to an increased cellular radiotoxicity we investi¬gated in SCL II-cells whether photon activation of intracellular located nano-sized gold par¬ticles is feasible to enhance cyto- and genotoxic effects in vitro.SCL II-cells were transfected with colloidal nano-sized gold particles (40 nm) and gold-labeled DNA-triplex-forming-oligonucleotides and irradiated with a suitable 170Tm source (micro seeds). Genotoxicity was assessed using the Micronucleus-Assay and cytotoxicity was in-vestigated using the Colony-Forming-Assay.Preliminary results indicate that Nanogold-labeled SCL II-cells show a 2-fold increase in micronucleus formation when compared to irradiated non-labeled cells. Non-irradiated Nanogold-labeled SCL II-cells showed the same background level of micronucleated cells as non-labeled SCLII-cells. The mitotic activity was neither disturbed by the gold-labeling nor the transfection procedure. Cytotoxic effects are less prominent but still need further investi¬gation. Photon activation might be a promising approach to increase the biological effectiveness of low-LET-radiation and might be of great value for new brachytherapy strategies.This work is financially supported by STEP Pockau GmbH |
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| 700 | 1 | _ | |a Pomplun, Ekkehard |0 P:(DE-Juel1)133341 |b 3 |
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