000841560 001__ 841560
000841560 005__ 20210129232034.0
000841560 0247_ $$2doi$$a10.1021/acs.jnatprod.7b00477
000841560 0247_ $$2pmid$$apmid:29094598
000841560 0247_ $$2WOS$$aWOS:000416500400011
000841560 0247_ $$2altmetric$$aaltmetric:28341121
000841560 037__ $$aFZJ-2017-08598
000841560 082__ $$a500
000841560 1001_ $$0P:(DE-HGF)0$$aMokhlesi, Amin$$b0
000841560 245__ $$aCyclic Cystine-Bridged Peptides from the Marine Sponge Clathria basilana Induce Apoptosis in Tumor Cells and Depolarize the Bacterial Cytoplasmic Membrane
000841560 260__ $$aWashington, DC$$bSoc.$$c2017
000841560 3367_ $$2DRIVER$$aarticle
000841560 3367_ $$2DataCite$$aOutput Types/Journal article
000841560 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1520840862_25957
000841560 3367_ $$2BibTeX$$aARTICLE
000841560 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000841560 3367_ $$00$$2EndNote$$aJournal Article
000841560 520__ $$aInvestigation of the sponge Clathria basilana collected in Indonesia afforded five new peptides, including microcionamides C (1) and D (2), gombamides B (4), C (5), and D (6), and an unusual amide, (E)-2-amino-3-methyl-N-styrylbutanamide (7), along with 11 known compounds, among them microcionamide A (3). The structures of the new compounds were elucidated by one- and two-dimensional NMR spectroscopy as well as by high-resolution mass spectrometry. The absolute configurations of the constituent amino acid residues in 1–7 were determined by Marfey’s analysis. Microcionamides A, C, and D (1–3) showed in vitro cytotoxicity against lymphoma (Ramos) and leukemia cell lines (HL-60, Nomo-1, Jurkat J16), as well as against a human ovarian carcinoma cell line (A2780) with IC50 values ranging from 0.45 to 28 μM. Mechanistic studies showed that compounds 1–3 rapidly induce apoptotic cell death in Jurkat J16 and Ramos cells and that 1 and 2 potently block autophagy upon starvation conditions, thereby impairing pro-survival signaling of cancer cells. In addition, microcionamides C and A (1 and 3) inhibited bacterial growth of Staphylococcus aureus and Enterococcus faecium with minimal inhibitory concentrations between 6.2 and 12 μM. Mechanistic studies indicate dissipation of the bacterial membrane potential.
000841560 536__ $$0G:(DE-HGF)POF3-551$$a551 - Functional Macromolecules and Complexes (POF3-551)$$cPOF3-551$$fPOF III$$x0
000841560 588__ $$aDataset connected to CrossRef
000841560 7001_ $$0P:(DE-HGF)0$$aStuhldreier, Fabian$$b1
000841560 7001_ $$0P:(DE-HGF)0$$aWex, Katharina W.$$b2
000841560 7001_ $$0P:(DE-HGF)0$$aBerscheid, Anne$$b3
000841560 7001_ $$0P:(DE-Juel1)132001$$aHartmann, Rudolf$$b4$$ufzj
000841560 7001_ $$0P:(DE-HGF)0$$aRehberg, Nidja$$b5
000841560 7001_ $$0P:(DE-HGF)0$$aSureechatchaiyan, Parichat$$b6
000841560 7001_ $$0P:(DE-HGF)0$$aChaidir, Chaidir$$b7
000841560 7001_ $$0P:(DE-HGF)0$$aKassack, Matthias$$b8
000841560 7001_ $$0P:(DE-HGF)0$$aKalscheuer, Rainer$$b9
000841560 7001_ $$0P:(DE-HGF)0$$aBrötz-Oesterhelt, Heike$$b10
000841560 7001_ $$0P:(DE-HGF)0$$aWesselborg, Sebastian$$b11
000841560 7001_ $$0P:(DE-HGF)0$$aStork, Björn$$b12
000841560 7001_ $$0P:(DE-HGF)0$$aDaletos, Georgios$$b13$$eCorresponding author
000841560 7001_ $$0P:(DE-HGF)0$$aProksch, Peter$$b14$$eCorresponding author
000841560 773__ $$0PERI:(DE-600)1491522-4$$a10.1021/acs.jnatprod.7b00477$$gVol. 80, no. 11, p. 2941 - 2952$$n11$$p2941–2952$$tJournal of natural products$$v80$$x0163-3864$$y2017
000841560 8564_ $$uhttps://juser.fz-juelich.de/record/841560/files/acs.jnatprod.7b00477.pdf$$yRestricted
000841560 8564_ $$uhttps://juser.fz-juelich.de/record/841560/files/acs.jnatprod.7b00477.gif?subformat=icon$$xicon$$yRestricted
000841560 8564_ $$uhttps://juser.fz-juelich.de/record/841560/files/acs.jnatprod.7b00477.jpg?subformat=icon-1440$$xicon-1440$$yRestricted
000841560 8564_ $$uhttps://juser.fz-juelich.de/record/841560/files/acs.jnatprod.7b00477.jpg?subformat=icon-180$$xicon-180$$yRestricted
000841560 8564_ $$uhttps://juser.fz-juelich.de/record/841560/files/acs.jnatprod.7b00477.jpg?subformat=icon-640$$xicon-640$$yRestricted
000841560 8564_ $$uhttps://juser.fz-juelich.de/record/841560/files/acs.jnatprod.7b00477.pdf?subformat=pdfa$$xpdfa$$yRestricted
000841560 909CO $$ooai:juser.fz-juelich.de:841560$$pVDB
000841560 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)132001$$aForschungszentrum Jülich$$b4$$kFZJ
000841560 9131_ $$0G:(DE-HGF)POF3-551$$1G:(DE-HGF)POF3-550$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lBioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences$$vFunctional Macromolecules and Complexes$$x0
000841560 9141_ $$y2018
000841560 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000841560 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ NAT PROD : 2015
000841560 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000841560 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000841560 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000841560 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000841560 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000841560 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000841560 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000841560 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences
000841560 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000841560 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record
000841560 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000841560 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000841560 920__ $$lyes
000841560 9201_ $$0I:(DE-Juel1)ICS-6-20110106$$kICS-6$$lStrukturbiochemie $$x0
000841560 980__ $$ajournal
000841560 980__ $$aVDB
000841560 980__ $$aI:(DE-Juel1)ICS-6-20110106
000841560 980__ $$aUNRESTRICTED
000841560 981__ $$aI:(DE-Juel1)IBI-7-20200312