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@ARTICLE{Mokhlesi:841560,
      author       = {Mokhlesi, Amin and Stuhldreier, Fabian and Wex, Katharina
                      W. and Berscheid, Anne and Hartmann, Rudolf and Rehberg,
                      Nidja and Sureechatchaiyan, Parichat and Chaidir, Chaidir
                      and Kassack, Matthias and Kalscheuer, Rainer and
                      Brötz-Oesterhelt, Heike and Wesselborg, Sebastian and
                      Stork, Björn and Daletos, Georgios and Proksch, Peter},
      title        = {{C}yclic {C}ystine-{B}ridged {P}eptides from the {M}arine
                      {S}ponge {C}lathria basilana {I}nduce {A}poptosis in {T}umor
                      {C}ells and {D}epolarize the {B}acterial {C}ytoplasmic
                      {M}embrane},
      journal      = {Journal of natural products},
      volume       = {80},
      number       = {11},
      issn         = {0163-3864},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {FZJ-2017-08598},
      pages        = {2941–2952},
      year         = {2017},
      abstract     = {Investigation of the sponge Clathria basilana collected in
                      Indonesia afforded five new peptides, including
                      microcionamides C (1) and D (2), gombamides B (4), C (5),
                      and D (6), and an unusual amide,
                      (E)-2-amino-3-methyl-N-styrylbutanamide (7), along with 11
                      known compounds, among them microcionamide A (3). The
                      structures of the new compounds were elucidated by one- and
                      two-dimensional NMR spectroscopy as well as by
                      high-resolution mass spectrometry. The absolute
                      configurations of the constituent amino acid residues in
                      1–7 were determined by Marfey’s analysis.
                      Microcionamides A, C, and D (1–3) showed in vitro
                      cytotoxicity against lymphoma (Ramos) and leukemia cell
                      lines (HL-60, Nomo-1, Jurkat J16), as well as against a
                      human ovarian carcinoma cell line (A2780) with IC50 values
                      ranging from 0.45 to 28 μM. Mechanistic studies showed that
                      compounds 1–3 rapidly induce apoptotic cell death in
                      Jurkat J16 and Ramos cells and that 1 and 2 potently block
                      autophagy upon starvation conditions, thereby impairing
                      pro-survival signaling of cancer cells. In addition,
                      microcionamides C and A (1 and 3) inhibited bacterial growth
                      of Staphylococcus aureus and Enterococcus faecium with
                      minimal inhibitory concentrations between 6.2 and 12 μM.
                      Mechanistic studies indicate dissipation of the bacterial
                      membrane potential.},
      cin          = {ICS-6},
      ddc          = {500},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29094598},
      UT           = {WOS:000416500400011},
      doi          = {10.1021/acs.jnatprod.7b00477},
      url          = {https://juser.fz-juelich.de/record/841560},
}