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@ARTICLE{Malter:841764,
      author       = {Malter, M. P. and Choi, S. and Fink, G. R.},
      title        = {{C}erebrospinal fluid findings in non-infectious status
                      epilepticus},
      journal      = {Epilepsy research},
      volume       = {140},
      issn         = {0920-1211},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2018-00068},
      pages        = {61 - 65},
      year         = {2018},
      abstract     = {ObjectiveIctal activity itself can cause pathological
                      cerebrospinal fluid (CSF) findings. However, data regarding
                      pathological CSF findings caused by SE itself to date remain
                      scarce. We here evaluated the frequency and specificity of
                      pathological CSF findings in non-infectious SE.MethodsWe
                      performed a retrospective analysis of CSF samples in adult
                      patients with episodes of non-infectious SE, who had been
                      admitted to the Department of Neurology, University Hospital
                      of Cologne. The following parameters were assessed: cell
                      count, protein, and lactate content, CSF/serum glucose
                      quotient (QGlc), disturbances of blood-brain-barrier
                      function assessed by CSF/serum albumin quotient (QAlb), and
                      qualitative intrathecal IgG synthesis assessed by unmatched
                      oligoclonal bands in CSF.ResultsWe analysed 54 episodes of
                      non-infectious SE in which CSF had been obtained. CSF
                      pleocytosis was infrequent $(6\%).$ Elevated CSF protein
                      content was present in $44\%$ of all cases, whereas elevated
                      CSF lactate content was found in $23\%$ of the cases. A
                      decreased QGlc was present in $9\%.$ Dysfunction of
                      blood-brain-barrier (BBBD) was the most frequent
                      pathological finding, amounting to $55\%.$ Unmatched
                      oligoclonal bands in CSF were seen in $10\%$ of
                      non-infectious SE.Further analysis revealed that elevated
                      CSF protein content was found predominantly in recfractory
                      SE (p = 0.04). Elevated CSF lactate content was
                      associated with shorter latency between onset of SE and CSF
                      retrieval (p = 0.004), positive history of epilepsy
                      (p = 0.02) and an acute symptomatic etiology
                      (p = 0.04). BBBD was also present more often in acute
                      symptomatic SE (p = 0.001) and was the sole pathological
                      CSF parameter associated with clinical outcome: presence of
                      BBBD was associated with a less favorable outcome
                      (p = 0.02).SignificanceNon-infectious SE itself does not
                      commonly cause CSF pleocytosis. Data suggest that the
                      detection of CSF pleocytosis should prompt further
                      diagnostics for an underlying infectious or neoplastic
                      etiology. In contrast, elevation of CSF protein content and
                      BBBD were found frequently in non-infectious SE.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29276970},
      UT           = {WOS:000427337600010},
      doi          = {10.1016/j.eplepsyres.2017.12.008},
      url          = {https://juser.fz-juelich.de/record/841764},
}