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000841765 1001_ $$00000-0001-5097-2631$$aMaus, Volker$$b0$$eCorresponding author
000841765 245__ $$aMechanical Thrombectomy in Basilar Artery Occlusion
000841765 260__ $$aMünchen$$bUrban & Vogel$$c2019
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000841765 520__ $$aBackgroundMechanical thrombectomy (MT) of basilar artery occlusions (BAO) is a subject of debate. We investigated the clinical outcome of MT in BAO and predictors of a favorable outcome.Material and MethodsA total of 104 MTs of BAO (carried out between 2010 and 2016) were analyzed. Favorable outcome as a modified Rankin scale (mRS) ≤ 2 at 90 days was the primary endpoint. The influence of the following variables on outcome was investigated: number of detectable posterior communicating arteries (PcoAs), patency of basilar tip, completeness of BAO and posterior circulation Alberta Stroke Program early computed tomography score (PC-ASPECTS). Secondary endpoints were technical periprocedural parameters including symptomatic intracranial hemorrhage (sICH).ResultsThe favorable clinical outcome at 90 days was 25% and mortality was 43%. The rate of successful reperfusion, i.e. modified thrombolysis in cerebral infarction (mTICI) ≥ 2b was 82%. Presence of bilateral PcoAs (area under the curve, AUC: 0.81, odds ratio, OR: 4.2, 2.2–8.2; p < 0.0001), lower National Institute of Health Stroke Scale (NIHSS) on admission (AUC: 0.74, OR: 2.6, 1.3–5.2; p < 0.01), PC-ASPECTS ≥ 9 (AUC: 0.72, OR: 4.2, 1.5–11.9; p < 0.01), incomplete BAO (AUC: 0.66, OR: 2.6, 1.4–4.8; p < 0.001), and basilar tip patency (AUC: 0.66, OR: 2.5, 1.3–4.8; p < 0.01) were associated with a favorable outcome. Stepwise logistic regression analysis revealed that the strongest predictors of favorable outcome at 90 days were bilateral PcoAs, low NIHSS on admission, and incomplete BAO (AUC: 0.923, OR: 7.2, 3–17.3; p < 0.0001).ConclusionThe use of MT for BAO is safe with high rates of successful reperfusion. Aside from baseline NIHSS and incomplete vessel occlusion, both known predictors of favorable outcome in anterior circulation events, we found that collateral flow based on the presence or absence of PcoAs had a decisive prognostic impact.
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000841765 7001_ $$0P:(DE-HGF)0$$aKalkan, Alev$$b1
000841765 7001_ $$0P:(DE-HGF)0$$aKabbasch, Christoph$$b2
000841765 7001_ $$0P:(DE-HGF)0$$aAbdullayev, Nuran$$b3
000841765 7001_ $$0P:(DE-HGF)0$$aStetefeld, Henning$$b4
000841765 7001_ $$0P:(DE-Juel1)131615$$aBarnikol, Utako Birgit$$b5
000841765 7001_ $$0P:(DE-HGF)0$$aLiebig, Thomas$$b6
000841765 7001_ $$0P:(DE-HGF)0$$aDohmen, Christian$$b7
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000841765 7001_ $$0P:(DE-HGF)0$$aBorggrefe, Jan$$b9
000841765 7001_ $$0P:(DE-HGF)0$$aMpotsaris, Anastasios$$b10
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