TY - JOUR AU - Kusen, Peter M. AU - Hoffmann, Kyra AU - Wandrey, Georg AU - Büchs, Jochen AU - Pietruszka, Jörg TI - Optische Genregulation in Mikrobioreaktoren JO - Biospektrum VL - 23 IS - 6 SN - 0947-0867 CY - Heidelberg PB - Spektrum M1 - FZJ-2018-00136 SP - 643-645 PY - 2017 AB - Photolabile-caged effector molecules allow non-invasive regulation of gene expression using cell-compatible UVA-irradiation. Based on this method, independent photoregulation of gene expression was combined with optical online monitoring of important cultivation parameters in a 48-well plate format. Thereby, an innovative screening system was created which allows for cost-effective and easily automated expression profiling as well as closed-loop process control. LB - PUB:(DE-HGF)16 DO - DOI:10.1007/s12268-017-0850-0 UR - https://juser.fz-juelich.de/record/841835 ER -