TY  - JOUR
AU  - Worgull, Dennis
AU  - Öhler, Laura
AU  - Strache, Joss Pepe
AU  - Friedrichs, Teresa
AU  - Ullrich, Patrick
TI  - Enantioselective Synthesis of 2,3-Dihydrofurans via Ammonium Ylides
JO  - European journal of organic chemistry
VL  - 2017
IS  - 40
SN  - 1434-193X
CY  - Weinheim
PB  - Wiley-VCH Verl.
M1  - FZJ-2018-00137
SP  - 6077 - 6080
PY  - 2017
AB  - A chiral, ammonium ylide based access to tetrasubstituted 2,3-dihydrofurans starting from readily available benzylidene dicarbonyls and bromo acetophenones has been developed. The products are obtained in moderate to good yields with excellent diasteroselectivity and good to excellent enantioselectivity (up to 99:1 e.r.). The employed chiral amine can be recovered in near quantitative yield. The transformation can be run as a three-component one-pot reaction, generating the ammonium salt and ylide in situ. The scope of this reaction includes 17 new dihydrofurans with aromatic or heteroaromatic substituents.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000414341700015
DO  - DOI:10.1002/ejoc.201701176
UR  - https://juser.fz-juelich.de/record/841836
ER  -