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@ARTICLE{Felder:841864,
      author       = {Felder, Jörg and Celik, A. Avdo and Choi, Chang-Hoon and
                      Schwan, Stefan and Shah, N. J.},
      title        = {9.4 {T} small animal {MRI} using clinical components for
                      direct translational studies},
      journal      = {Journal of translational medicine},
      volume       = {15},
      number       = {1},
      issn         = {1479-5876},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {FZJ-2018-00161},
      pages        = {264},
      year         = {2017},
      abstract     = {BackgroundMagnetic resonance is a major preclinical and
                      clinical imaging modality ideally suited for longitudinal
                      studies, e.g. in pharmacological developments. The lack of a
                      proven platform that maintains an identical imaging protocol
                      between preclinical and clinical platforms is solved with
                      the construction of an animal scanner based on clinical
                      hard- and software.MethodsA small animal magnet and gradient
                      system were connected to a clinical MR system. Several
                      hardware components were either modified or built in-house
                      to achieve compatibility. The clinical software was modified
                      to account for the different field-of-view of a preclinical
                      MR system. The established scanner was evaluated using
                      clinical QA protocols, and platform compatibility for
                      translational research was verified against clinical
                      scanners of different field strength.ResultsThe constructed
                      animal scanner operates with the majority of clinical
                      imaging sequences. Translational research is greatly
                      facilitated as protocols can be shared between preclinical
                      and clinical platforms. Hence, when maintaining sequences
                      parameters, maximum similarity between pulses played out on
                      a human or an animal system is maintained.ConclusionCoupling
                      of a small animal magnet with a clinical MR system is a
                      flexible, easy to use way to establish and advance
                      translational imaging capability. It provides cost and labor
                      efficient translational capability as no tedious sequence
                      reprogramming between moieties is required and
                      cross-platform compatibility of sequences facilitates
                      multi-center studies.},
      cin          = {INM-4 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29282070},
      UT           = {WOS:000418863800001},
      doi          = {10.1186/s12967-017-1373-7},
      url          = {https://juser.fz-juelich.de/record/841864},
}