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@ARTICLE{Tse:842038,
      author       = {Tse, Desmond H. Y. and da Silva, Nuno Andre and Poser,
                      Benedikt A. and Shah, N. J.},
      title        = {{B}1+ inhomogeneity mitigation in {CEST} using parallel
                      transmission},
      journal      = {Magnetic resonance in medicine},
      volume       = {78},
      number       = {6},
      issn         = {0740-3194},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2018-00322},
      pages        = {2216 - 2225},
      year         = {2017},
      abstract     = {PurposeIn order to benefit from the increased spectral
                      bandwidth at ultrahigh field (UHF), the use of parallel
                      transmission (pTx) to mitigate flip-angle inhomogeneity in
                      chemical exchange saturation transfer (CEST) imaging is
                      investigated.Theory and MethodsA pTx basis pulse is
                      homogenised by magnitude least-squares (MLS) optimization
                      and expanded to form a frequency-selective saturation pulse
                      for CEST. The pTx saturation pulse was simulated with a
                      three-pool Bloch-McConnell equation to evaluate the impact
                      of pTx on CEST contrast. In vivo CEST imaging performance (7
                      T) of the pTx saturation pulse and the standard Gaussian
                      saturation in circularly polarized mode were compared.
                      Two-spokes pTx homogeneous excitation was used in all in
                      vivo experiments to ensure fair comparison of the two
                      saturation pulses. Magnetization transfer ratio and inverse
                      Z-spectrum analyses were used as metrics in evaluating the
                      data from 3 healthy volunteers.ResultsBloch-McConnell
                      simulations showed that side bands of the pTx saturation
                      pulse at ±20 ppm did not affect any CEST contrast. Improved
                      homogeneity in contrasts and relaxation-compensated CEST
                      metrics were observed in our in vivo data when the pTx
                      saturation pulse was used.ConclusionA pTx-based pulsed CEST
                      presaturation scheme is proposed and validated by
                      simulations and 7T in vivo imaging. Magn Reson Med
                      78:2216–2225, 2017. © 2017 International Society for
                      Magnetic Resonance in Medicine.},
      cin          = {INM-4 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28244138},
      UT           = {WOS:000414967400015},
      doi          = {10.1002/mrm.26624},
      url          = {https://juser.fz-juelich.de/record/842038},
}