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000842041 1001_ $$0P:(DE-Juel1)131782$$aOros-Peusquens, A. M.$$b0$$eCorresponding author
000842041 245__ $$aMethods for molecular imaging of brain tumours in a hybrid MR-PET context: Water content, T 2 ∗ , diffusion indices and FET-PET
000842041 260__ $$aOrlando, Fla.$$bAcademic Press$$c2017
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000842041 520__ $$aThe aim of this study is to present and evaluate a multiparametric and multi-modality imaging protocol applied to brain tumours and investigate correlations between these different imaging measures. In particular, we describe a method for rapid, non-invasive, quantitative imaging of water content of brain tissue, based on a single multiple-echo gradient-echo (mGRE) acquisition. We include in the processing a method for noise reduction of the multi-contrast data based on Principal Component Analysis (PCA). Noise reduction is a key ingredient to obtaining high-precision water content and transverse relaxation T2∗ values. The quantitative method is applied to brain tumour patients in a hybrid MR-PET environment. Active tumour tissue is identified by means of FET-PET; oedema, white and grey-matter segmentation is performed based on MRI contrasts. Water content information is not only relevant by itself, but also as a basis for correlations with other quantitative measures of water behaviour in tissue and interpreting the microenvironment of water. Water content in active tumour tissue (84%) and oedema (79%) regions is found to be higher than that of normal WM (69%) and close to that of normal GM (83%). Consistent with literature reports, mean kurtosis is measured to be lower in tumour and oedema regions than in normal WM and GM, whereas mean diffusivity is increased. Voxel-based correlations between water content and diffusion indices obtained with diffusion kurtosis tensor imaging, and between quantitative MRI and FET-PET are reported for 8 brain tumour patients. The effective transverse relaxation time T2∗ is found to be the MR parameter showing the strongest correlations with other MR indices derived here and with FET-PET.
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000842041 7001_ $$0P:(DE-Juel1)169114$$aLoução, R.$$b1
000842041 7001_ $$0P:(DE-Juel1)162442$$aZimmermann, Markus$$b2$$ufzj
000842041 7001_ $$0P:(DE-Juel1)131777$$aLangen, K.-J.$$b3
000842041 7001_ $$0P:(DE-Juel1)131794$$aShah, N. J.$$b4
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