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000842131 1001_ $$0P:(DE-Juel1)170083$$aVolkov, Oleksandr$$b0$$ufzj
000842131 245__ $$aStructural insights into ion conduction by channelrhodopsin 2
000842131 260__ $$aWashington, DC [u.a.]$$bAmerican Association for the Advancement of Science$$c2017
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000842131 520__ $$aIon channels are integral membrane proteins that upon stimulation modulate the flow of ions across the cell or organelle membrane. The resulting electrical signals are involved in biological functions such as electrochemical transmission and information processing in neurons. Channelrhodopsins (ChRs) appear to be unusual channels. They belong to the large family of microbial rhodopsins, seven-helical transmembrane proteins containing retinal as chromophore. Photon absorption initiates retinal isomerization resulting in a photocycle, with different spectroscopically distinguishable intermediates, thereby controlling the opening and closing of the channel. In 2003, it was demonstrated that light-induced currents by heterologously expressed ChR2 can be used to change a host’s membrane potential. The concept was further applied to precisely control muscle and neural activity by using light-induced depolarization to trigger an action potential in neurons expressing ChR2. This optogenetic approach with ChR2 and other ChRs has been widely used for remote control of neural cells in culture and in living animals with high spatiotemporal resolution. It is also used in biomedical studies aimed to cure severe diseases.
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000842131 7001_ $$0P:(DE-Juel1)169220$$aKovalev, Kirill$$b1$$ufzj
000842131 7001_ $$0P:(DE-HGF)0$$apolovinkin$$b2
000842131 7001_ $$0P:(DE-Juel1)144613$$aBorshchevskiy, Valentin$$b3
000842131 7001_ $$0P:(DE-HGF)0$$aBamann, Christian$$b4
000842131 7001_ $$0P:(DE-HGF)0$$aAstashkin, Roman$$b5
000842131 7001_ $$0P:(DE-HGF)0$$aMarin, Egor$$b6
000842131 7001_ $$0P:(DE-HGF)0$$aPopov, Alexander$$b7
000842131 7001_ $$0P:(DE-Juel1)131949$$aBalandin, Taras$$b8$$ufzj
000842131 7001_ $$0P:(DE-Juel1)132029$$aWillbold, Dieter$$b9$$ufzj
000842131 7001_ $$0P:(DE-Juel1)131957$$aBüldt, Georg$$b10
000842131 7001_ $$0P:(DE-HGF)0$$aBamberg, Ernst$$b11$$eCorresponding author
000842131 7001_ $$0P:(DE-Juel1)131964$$aGordeliy, Valentin$$b12$$eCorresponding author$$ufzj
000842131 773__ $$0PERI:(DE-600)2066996-3$$a10.1126/science.aan8862$$n6366$$peaan8862$$tScience$$v358$$x0193-4511$$y2017
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