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@ARTICLE{Volkov:842131,
      author       = {Volkov, Oleksandr and Kovalev, Kirill and polovinkin and
                      Borshchevskiy, Valentin and Bamann, Christian and Astashkin,
                      Roman and Marin, Egor and Popov, Alexander and Balandin,
                      Taras and Willbold, Dieter and Büldt, Georg and Bamberg,
                      Ernst and Gordeliy, Valentin},
      title        = {{S}tructural insights into ion conduction by
                      channelrhodopsin 2},
      journal      = {Science},
      volume       = {358},
      number       = {6366},
      issn         = {0193-4511},
      address      = {Washington, DC [u.a.]},
      publisher    = {American Association for the Advancement of Science},
      reportid     = {FZJ-2018-00410},
      pages        = {eaan8862},
      year         = {2017},
      abstract     = {Ion channels are integral membrane proteins that upon
                      stimulation modulate the flow of ions across the cell or
                      organelle membrane. The resulting electrical signals are
                      involved in biological functions such as electrochemical
                      transmission and information processing in neurons.
                      Channelrhodopsins (ChRs) appear to be unusual channels. They
                      belong to the large family of microbial rhodopsins,
                      seven-helical transmembrane proteins containing retinal as
                      chromophore. Photon absorption initiates retinal
                      isomerization resulting in a photocycle, with different
                      spectroscopically distinguishable intermediates, thereby
                      controlling the opening and closing of the channel. In 2003,
                      it was demonstrated that light-induced currents by
                      heterologously expressed ChR2 can be used to change a
                      host’s membrane potential. The concept was further applied
                      to precisely control muscle and neural activity by using
                      light-induced depolarization to trigger an action potential
                      in neurons expressing ChR2. This optogenetic approach with
                      ChR2 and other ChRs has been widely used for remote control
                      of neural cells in culture and in living animals with high
                      spatiotemporal resolution. It is also used in biomedical
                      studies aimed to cure severe diseases.},
      cin          = {ICS-6},
      ddc          = {500},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29170206},
      UT           = {WOS:000416590400032},
      doi          = {10.1126/science.aan8862},
      url          = {https://juser.fz-juelich.de/record/842131},
}