guest ::
| Home > Publications database > Structural insights into ion conduction by channelrhodopsin 2 > print |
| Home > Publications database > Structural insights into ion conduction by channelrhodopsin 2 > print |
| 001 | 842131 | ||
| 005 | 20210129232215.0 | ||
| 024 | 7 | _ | |a 10.1126/science.aan8862 |2 doi |
| 024 | 7 | _ | |a pmid:29170206 |2 pmid |
| 024 | 7 | _ | |a WOS:000416590400032 |2 WOS |
| 024 | 7 | _ | |a altmetric:29344553 |2 altmetric |
| 037 | _ | _ | |a FZJ-2018-00410 |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |0 P:(DE-Juel1)170083 |a Volkov, Oleksandr |b 0 |u fzj |
| 245 | _ | _ | |a Structural insights into ion conduction by channelrhodopsin 2 |
| 260 | _ | _ | |a Washington, DC [u.a.] |b American Association for the Advancement of Science |c 2017 |
| 336 | 7 | _ | |2 DRIVER |a article |
| 336 | 7 | _ | |2 DataCite |a Output Types/Journal article |
| 336 | 7 | _ | |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |a Journal Article |b journal |m journal |s 1515761709_31878 |
| 336 | 7 | _ | |2 BibTeX |a ARTICLE |
| 336 | 7 | _ | |2 ORCID |a JOURNAL_ARTICLE |
| 336 | 7 | _ | |0 0 |2 EndNote |a Journal Article |
| 520 | _ | _ | |a Ion channels are integral membrane proteins that upon stimulation modulate the flow of ions across the cell or organelle membrane. The resulting electrical signals are involved in biological functions such as electrochemical transmission and information processing in neurons. Channelrhodopsins (ChRs) appear to be unusual channels. They belong to the large family of microbial rhodopsins, seven-helical transmembrane proteins containing retinal as chromophore. Photon absorption initiates retinal isomerization resulting in a photocycle, with different spectroscopically distinguishable intermediates, thereby controlling the opening and closing of the channel. In 2003, it was demonstrated that light-induced currents by heterologously expressed ChR2 can be used to change a host’s membrane potential. The concept was further applied to precisely control muscle and neural activity by using light-induced depolarization to trigger an action potential in neurons expressing ChR2. This optogenetic approach with ChR2 and other ChRs has been widely used for remote control of neural cells in culture and in living animals with high spatiotemporal resolution. It is also used in biomedical studies aimed to cure severe diseases. |
| 536 | _ | _ | |0 G:(DE-HGF)POF3-551 |a 551 - Functional Macromolecules and Complexes (POF3-551) |c POF3-551 |f POF III |x 0 |
| 700 | 1 | _ | |0 P:(DE-Juel1)169220 |a Kovalev, Kirill |b 1 |u fzj |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a polovinkin |b 2 |
| 700 | 1 | _ | |0 P:(DE-Juel1)144613 |a Borshchevskiy, Valentin |b 3 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Bamann, Christian |b 4 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Astashkin, Roman |b 5 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Marin, Egor |b 6 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Popov, Alexander |b 7 |
| 700 | 1 | _ | |0 P:(DE-Juel1)131949 |a Balandin, Taras |b 8 |u fzj |
| 700 | 1 | _ | |0 P:(DE-Juel1)132029 |a Willbold, Dieter |b 9 |u fzj |
| 700 | 1 | _ | |0 P:(DE-Juel1)131957 |a Büldt, Georg |b 10 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Bamberg, Ernst |b 11 |e Corresponding author |
| 700 | 1 | _ | |0 P:(DE-Juel1)131964 |a Gordeliy, Valentin |b 12 |e Corresponding author |u fzj |
| 773 | _ | _ | |0 PERI:(DE-600)2066996-3 |a 10.1126/science.aan8862 |n 6366 |p eaan8862 |t Science |v 358 |x 0193-4511 |y 2017 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/842131/files/eaan8862.full.pdf |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/842131/files/eaan8862.full.gif?subformat=icon |x icon |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/842131/files/eaan8862.full.jpg?subformat=icon-1440 |x icon-1440 |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/842131/files/eaan8862.full.jpg?subformat=icon-180 |x icon-180 |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/842131/files/eaan8862.full.jpg?subformat=icon-640 |x icon-640 |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/842131/files/eaan8862.full.pdf?subformat=pdfa |x pdfa |y Restricted |
| 909 | C | O | |o oai:juser.fz-juelich.de:842131 |p VDB |
| 910 | 1 | _ | |0 I:(DE-588b)5008462-8 |6 P:(DE-Juel1)170083 |a Forschungszentrum Jülich |b 0 |k FZJ |
| 910 | 1 | _ | |0 I:(DE-588b)5008462-8 |6 P:(DE-Juel1)169220 |a Forschungszentrum Jülich |b 1 |k FZJ |
| 910 | 1 | _ | |0 I:(DE-588b)5008462-8 |6 P:(DE-HGF)0 |a Forschungszentrum Jülich |b 2 |k FZJ |
| 910 | 1 | _ | |0 I:(DE-588b)5008462-8 |6 P:(DE-Juel1)131949 |a Forschungszentrum Jülich |b 8 |k FZJ |
| 910 | 1 | _ | |0 I:(DE-588b)5008462-8 |6 P:(DE-Juel1)132029 |a Forschungszentrum Jülich |b 9 |k FZJ |
| 910 | 1 | _ | |0 I:(DE-588b)5008462-8 |6 P:(DE-Juel1)131964 |a Forschungszentrum Jülich |b 12 |k FZJ |
| 913 | 1 | _ | |0 G:(DE-HGF)POF3-551 |1 G:(DE-HGF)POF3-550 |2 G:(DE-HGF)POF3-500 |a DE-HGF |b Key Technologies |l BioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences |v Functional Macromolecules and Complexes |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |
| 914 | 1 | _ | |y 2017 |
| 915 | _ | _ | |0 StatID:(DE-HGF)0300 |2 StatID |a DBCoverage |b Medline |
| 915 | _ | _ | |0 StatID:(DE-HGF)0310 |2 StatID |a DBCoverage |b NCBI Molecular Biology Database |
| 915 | _ | _ | |0 StatID:(DE-HGF)0600 |2 StatID |a DBCoverage |b Ebsco Academic Search |
| 915 | _ | _ | |0 StatID:(DE-HGF)0020 |2 StatID |a No Peer Review |b ASC |
| 920 | 1 | _ | |0 I:(DE-Juel1)ICS-6-20110106 |k ICS-6 |l Strukturbiochemie |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-Juel1)ICS-6-20110106 |
| 980 | _ | _ | |a UNRESTRICTED |
| 981 | _ | _ | |a I:(DE-Juel1)IBI-7-20200312 |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|