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@ARTICLE{Hoore:842288,
      author       = {Hoore, Masoud and Rack, Kathrin and Fedosov, Dmitry A and
                      Gompper, Gerhard},
      title        = {{F}low-induced adhesion of shear-activated polymers to a
                      substrate},
      journal      = {Journal of physics / Condensed matter},
      volume       = {30},
      number       = {6},
      issn         = {1361-648X},
      address      = {Bristol},
      publisher    = {IOP Publ.},
      reportid     = {FZJ-2018-00535},
      pages        = {064001},
      year         = {2018},
      abstract     = {Adhesion of polymers and proteins to substrates plays a
                      crucial role in many technological applications and
                      biological processes. A prominent example is the von
                      Willebrand factor (VWF) protein, which is essential in blood
                      clotting as it mediates adhesion of blood platelets to the
                      site of injury at high shear rates. VWF is activated by flow
                      and is able to bind efficiently to damaged vessel walls even
                      under extreme flow-stress conditions; however, its adhesion
                      is reversible when the flow strength is significantly
                      reduced or the flow is ceased. Motivated by the properties
                      and behavior of VWF in flow, we investigate adhesion of
                      shear-activated polymers to a planar wall in flow and
                      whether the adhesion is reversible under flow stasis. The
                      main ingredients of the polymer model are cohesive
                      inter-monomer interactions, a catch bond with the adhesive
                      surface, and the shear activation/deactivation of polymer
                      adhesion correlated with its stretching in flow. The
                      cohesive interactions within the polymer maintain a globular
                      conformation under low shear stresses and allow polymer
                      stretching if a critical shear rate is exceeded, which is
                      directly associated with its activation for adhesion. Our
                      results show that polymer adhesion at high shear rates is
                      significantly stabilized by catch bonds, while at the same
                      time they also permit polymer dissociation from a surface at
                      low or no flow stresses. In addition, the
                      activation/deactivation mechanism for adhesion plays a
                      crucial role in the reversibility of its adhesion. These
                      observations help us better understand the adhesive behavior
                      of VWF in flow and interpret its adhesion malfunctioning in
                      VWF-related diseases.},
      cin          = {ICS-2 / IAS-2 / JARA-HPC},
      ddc          = {530},
      cid          = {I:(DE-Juel1)ICS-2-20110106 / I:(DE-Juel1)IAS-2-20090406 /
                      $I:(DE-82)080012_20140620$},
      pnm          = {553 - Physical Basis of Diseases (POF3-553) / Margination
                      and Adhesion of Particles and Cells in Blood Flow
                      $(jiff44_20140501)$},
      pid          = {G:(DE-HGF)POF3-553 / $G:(DE-Juel1)jiff44_20140501$},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29297854},
      UT           = {WOS:000422878100001},
      doi          = {10.1088/1361-648X/aaa4d5},
      url          = {https://juser.fz-juelich.de/record/842288},
}