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000842466 1001_ $$00000-0001-5278-9937$$aShevchenko, Marina A.$$b0$$eCorresponding author
000842466 245__ $$aAspergillus fumigatus Infection-Induced Neutrophil Recruitment and Location in the Conducting Airway of Immunocompetent, Neutropenic, and Immunosuppressed Mice
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000842466 520__ $$aSusceptibility to fungal infection is commonly associated with impaired neutrophil responses. To study the mechanisms underlying this association, we investigated neutrophil recruitment to the conducting airway wall after Aspergillus fumigatus conidium inhalation in mouse models of drug-induced immunosuppression and antibody-mediated neutrophil depletion (neutropenia) by performing three-dimensional confocal laser-scanning microscopy of whole-mount primary bronchus specimens. Actin staining enabled visualization of the epithelial and smooth muscle layers that mark the airway wall. Gr-1+ or Ly6G+ neutrophils located between the epithelium and smooth muscles were considered airway wall neutrophils. The number of airway wall neutrophils for immunocompetent, immunosuppressed, and neutropenic mice before and 6 h after A. fumigatus infection were analyzed and compared. Our results show that the number of conducting airway wall neutrophils in immunocompetent mice significantly increased upon inflammation, while a dramatic reduction in this number was observed following immunosuppression and neutropenia. Interestingly, a slight increase in the infiltration of neutrophils into the airway wall was detected as a result of infection, even in immunosuppressed and neutropenic mice. Taken together, these data indicate that neutrophils are present in intact conducting airway walls and the number elevates upon A. fumigatus infection. Conducting airway wall neutrophils are affected by both neutropenia and immunosuppression.
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000842466 7001_ $$0P:(DE-HGF)0$$aBogorodskiy, Andrey O.$$b1
000842466 7001_ $$0P:(DE-HGF)0$$aTroyanova, Natalia I.$$b2
000842466 7001_ $$0P:(DE-HGF)0$$aServuli, Ekaterina A.$$b3
000842466 7001_ $$0P:(DE-HGF)0$$aBolkhovitina, Elena L.$$b4
000842466 7001_ $$0P:(DE-Juel1)131957$$aBüldt, Georg$$b5
000842466 7001_ $$0P:(DE-Juel1)136837$$aFahlke, Christoph$$b6
000842466 7001_ $$0P:(DE-Juel1)131964$$aGordeliy, Valentin$$b7
000842466 7001_ $$0P:(DE-Juel1)131924$$aGensch, Thomas$$b8
000842466 7001_ $$0P:(DE-Juel1)144613$$aBorshchevskiy, Valentin$$b9$$eCorresponding author
000842466 7001_ $$0P:(DE-HGF)0$$aSapozhnikov, Alexander M.$$b10
000842466 773__ $$0PERI:(DE-600)2817541-4$$a10.1155/2018/5379085$$gVol. 2018, p. 1 - 12$$nID 5379085$$p1 - 12$$tJournal of Immunology Research$$v2018$$x2314-7156$$y2018
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