% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Shevchenko:842466,
      author       = {Shevchenko, Marina A. and Bogorodskiy, Andrey O. and
                      Troyanova, Natalia I. and Servuli, Ekaterina A. and
                      Bolkhovitina, Elena L. and Büldt, Georg and Fahlke,
                      Christoph and Gordeliy, Valentin and Gensch, Thomas and
                      Borshchevskiy, Valentin and Sapozhnikov, Alexander M.},
      title        = {{A}spergillus fumigatus {I}nfection-{I}nduced {N}eutrophil
                      {R}ecruitment and {L}ocation in the {C}onducting {A}irway of
                      {I}mmunocompetent, {N}eutropenic, and {I}mmunosuppressed
                      {M}ice},
      journal      = {Journal of Immunology Research},
      volume       = {2018},
      number       = {ID 5379085},
      issn         = {2314-7156},
      address      = {New York, NY},
      publisher    = {Hindawi},
      reportid     = {FZJ-2018-00700},
      pages        = {1 - 12},
      year         = {2018},
      abstract     = {Susceptibility to fungal infection is commonly associated
                      with impaired neutrophil responses. To study the mechanisms
                      underlying this association, we investigated neutrophil
                      recruitment to the conducting airway wall after Aspergillus
                      fumigatus conidium inhalation in mouse models of
                      drug-induced immunosuppression and antibody-mediated
                      neutrophil depletion (neutropenia) by performing
                      three-dimensional confocal laser-scanning microscopy of
                      whole-mount primary bronchus specimens. Actin staining
                      enabled visualization of the epithelial and smooth muscle
                      layers that mark the airway wall. Gr-1+ or Ly6G+ neutrophils
                      located between the epithelium and smooth muscles were
                      considered airway wall neutrophils. The number of airway
                      wall neutrophils for immunocompetent, immunosuppressed, and
                      neutropenic mice before and 6 h after A. fumigatus
                      infection were analyzed and compared. Our results show that
                      the number of conducting airway wall neutrophils in
                      immunocompetent mice significantly increased upon
                      inflammation, while a dramatic reduction in this number was
                      observed following immunosuppression and neutropenia.
                      Interestingly, a slight increase in the infiltration of
                      neutrophils into the airway wall was detected as a result of
                      infection, even in immunosuppressed and neutropenic mice.
                      Taken together, these data indicate that neutrophils are
                      present in intact conducting airway walls and the number
                      elevates upon A. fumigatus infection. Conducting airway wall
                      neutrophils are affected by both neutropenia and
                      immunosuppression.},
      cin          = {ICS-4 / ICS-6},
      ddc          = {610},
      cid          = {I:(DE-Juel1)ICS-4-20110106 / I:(DE-Juel1)ICS-6-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29577051},
      UT           = {WOS:000423672400001},
      doi          = {10.1155/2018/5379085},
      url          = {https://juser.fz-juelich.de/record/842466},
}