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@ARTICLE{Sonnack:842554,
      author       = {Sonnack, Laura and Klawonn, Thorsten and Kriehuber, Ralf
                      and Hollert, Henner and Schäfers, Christoph and Fenske,
                      Martina},
      title        = {{C}omparative analysis of the transcriptome responses of
                      zebrafish embryos after exposure to low concentrations of
                      cadmium, cobalt and copper},
      journal      = {Comparative biochemistry and physiology / D},
      volume       = {25},
      issn         = {1744-117X},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2018-00773},
      pages        = {99 - 108},
      year         = {2018},
      abstract     = {Metal toxicity is a global environmental challenge. Fish
                      are particularly prone to metal exposure, which can be
                      lethal or cause sublethal physiological impairments. The
                      objective ofthis study was to investigate how adverse
                      effects of chronic exposure to non-toxic levels of essential
                      and non-essential metals in early life stage zebrafish may
                      be explained by changes inthe transcriptome. We therefore
                      studied the effects of three different metals at low
                      concentrations in zebrafish embryos by transcriptomics
                      analysis. The study design comparedexposure effects caused
                      by different metals at different developmental stages
                      (pre-hatch and post-hatch). Wild-type embryos were exposed
                      to solutions of low concentrations of copper(CuSO4), cadmium
                      (CdCl2) and cobalt (CoSO4) until 96 h post-fertilization
                      (hpf) and microarray experiments were carried out to
                      determine transcriptome profiles at 48 and 96 hpf.We found
                      that the toxic metal cadmium affected the expression of more
                      genes at 96 hpf than 48 hpf. The opposite effect was
                      observed for the essential metals cobalt and copper,
                      whichalso showed enrichment of different GO terms. Genes
                      involved in neuromast and motor neuron development were
                      significantly enriched, agreeing with our previous results
                      showingmotor neuron and neuromast damage in the embryos. Our
                      data provide evidence that the response of the transcriptome
                      of fish embryos to metal exposure differs for essential and
                      nonessential metals.},
      cin          = {S-US},
      ddc          = {540},
      cid          = {I:(DE-Juel1)S-US-20090406},
      pnm          = {899 - ohne Topic (POF3-899)},
      pid          = {G:(DE-HGF)POF3-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29287281},
      UT           = {WOS:000426535700011},
      doi          = {10.1016/j.cbd.2017.12.001},
      url          = {https://juser.fz-juelich.de/record/842554},
}