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@INPROCEEDINGS{Brzozowska:842640,
      author       = {Brzozowska, Kinga and Pinkawa, Michael and Eble, Michael
                      and Müller, Wolfgang-Ulrich and Wojcik, Andrzej and
                      Kriehuber, Ralf and Schmitz, Sabine},
      title        = {{C}omparison of individual radiosensitivity of peripheral
                      blood lymphocytes from prostate cancer patients and healthy
                      donors},
      reportid     = {FZJ-2018-00847},
      year         = {2010},
      abstract     = {Introduction: There is some evidence that approximately
                      $10\%$ of the population show an enhanced intrinsic
                      radiosensitivity of normal tissue and hence have a higher
                      risk for developing side-effects during or after
                      radiotherapy. For that reason there is a need for a fast and
                      robust test to assess normal tissue response to
                      radiotherapy. DNA repair deficiency and altered apoptosis
                      characteristics are discussed as promising markers of
                      radiosensitivity. The aim of our study was to find out
                      whether peripheral blood lymphocytes from cancer patients
                      with strong clinical side effects following radiotherapy as
                      assessed clinically on the basis of the EPIC questionnaire,
                      show enhanced rates of in vitro radiation-induced double
                      strand breaks (dsb), decreased DNA repair capacity and
                      altered induction of apoptosis when compared to lymphocytes
                      from patients without side effects and healthy age–matched
                      donors. Materials and methods: The study included 20
                      prostate cancer patients without and 20 patients with acute
                      side-effects during and after radiothrapy, as well as 20
                      healthy age-matched donors. From each donor, blood samples
                      were collected, exposed to a radiation dose of 0.5 Gy or 1
                      Gy of γ –rays and analysed for the following biological
                      endpoints: the initial level of dsb and the repair kinetics
                      (γ–H2AX–assay), apoptosis (Annexin V/PI–assay) and
                      the induction of chromatid–type chromosomal aberrations
                      (G2–assay). Results: Significant higher chromatid
                      aberration yield was found between prostate cancer patients
                      and healthy donors. Eleven patients which suffered because
                      of acute side-effects after radiotherapy showed an enhanced
                      aberration level. In addition, an elevated aberration level
                      was observed also in 11 patients without side-effects after
                      radiotherapy. No differences were observed between both
                      patients group in any in vitro assay. Based on the results
                      of all chosen assays 6 prostate cancer patients were
                      identified as cellular sensitive, whereof 4 of them were
                      also clinical sensitive.},
      month         = {Sep},
      date          = {2010-09-01},
      organization  = {13. Jahrestagung der Gesellschaft für
                       Biologische Strahlenforschung, Hamburg
                       (Germany), 1 Sep 2010 - 2 Sep 2010},
      subtyp        = {After Call},
      cin          = {S-US},
      cid          = {I:(DE-Juel1)S-US-20090406},
      pnm          = {899 - ohne Topic (POF3-899)},
      pid          = {G:(DE-HGF)POF3-899},
      typ          = {PUB:(DE-HGF)24},
      url          = {https://juser.fz-juelich.de/record/842640},
}