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@ARTICLE{Zerihun:842702,
      author       = {Zerihun, Mehari B. and Schug, Alexander},
      title        = {{B}iomolecular coevolution and its applications: {G}oing
                      from structure prediction toward signaling, epistasis, and
                      function},
      journal      = {Biochemical Society transactions},
      volume       = {45},
      number       = {6},
      issn         = {1470-8752},
      address      = {London},
      publisher    = {Portland Press},
      reportid     = {FZJ-2018-00909},
      pages        = {1253 - 1261},
      year         = {2017},
      abstract     = {Evolution leads to considerable changes in the sequence of
                      biomolecules, while their overall structure and function
                      remain quite conserved. The wealth of genomic sequences, the
                      ‘Biological Big Data’, modern sequencing techniques
                      provide allows us to investigate biomolecular evolution with
                      unprecedented detail. Sophisticated statistical models can
                      infer residue pair mutations resulting from spatial
                      proximity. The introduction of predicted spatial adjacencies
                      as constraints in biomolecular structure prediction
                      workflows has transformed the field of protein and RNA
                      structure prediction toward accuracies approaching the
                      experimental resolution limit. Going beyond structure
                      prediction, the same mathematical framework allows mimicking
                      evolutionary fitness landscapes to infer signaling
                      interactions, epistasis, or mutational landscapes.},
      cin          = {NIC / JSC},
      ddc          = {540},
      cid          = {I:(DE-Juel1)NIC-20090406 / I:(DE-Juel1)JSC-20090406},
      pnm          = {511 - Computational Science and Mathematical Methods
                      (POF3-511)},
      pid          = {G:(DE-HGF)POF3-511},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000418440200005},
      pubmed       = {pmid:29054926},
      doi          = {10.1042/BST20170063},
      url          = {https://juser.fz-juelich.de/record/842702},
}