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@ARTICLE{Radnikow:842723,
      author       = {Radnikow, Gabriele and Feldmeyer, Dirk},
      title        = {{L}ayer- and {C}ell {T}ype-{S}pecific {M}odulation of
                      {E}xcitatory {N}euronal {A}ctivity in the {N}eocortex},
      journal      = {Frontiers in neuroanatomy},
      volume       = {12},
      issn         = {1662-5129},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2018-00923},
      pages        = {1},
      year         = {2018},
      note         = {Record contains publication charges.},
      abstract     = {From an anatomical point of view the neocortex is
                      subdivided into up to six layers depending on the cortical
                      area. This subdivision has been described already by Meynert
                      and Brodmann in the late 19/early 20. century and is mainly
                      based on cytoarchitectonic features such as the size and
                      location of the pyramidal cell bodies. Hence, cortical
                      lamination is originally an anatomical concept based on the
                      distribution of excitatory neuron. However, it has become
                      apparent in recent years that apart from the layer-specific
                      differences in morphological features, many functional
                      properties of neurons are also dependent on cortical layer
                      or cell type. Such functional differences include changes in
                      neuronal excitability and synaptic activity by
                      neuromodulatory transmitters. Many of these neuromodulators
                      are released from axonal afferents from subcortical brain
                      regions while others are released intrinsically. In this
                      review we aim to describe layer- and cell-type specific
                      differences in the effects of neuromodulator receptors in
                      excitatory neurons in layers 2–6 of different cortical
                      areas. We will focus on the neuromodulator systems using
                      adenosine, acetylcholine, dopamine, and orexin/hypocretin as
                      examples because these neuromodulator systems show important
                      differences in receptor type and distribution, mode of
                      release and functional mechanisms and effects. We try to
                      summarize how layer- and cell type-specific neuromodulation
                      may affect synaptic signaling in cortical microcircuits.},
      cin          = {INM-2 / INM-10},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406 / I:(DE-Juel1)INM-10-20170113},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29440997},
      UT           = {WOS:000423551400001},
      doi          = {10.3389/fnana.2018.00001},
      url          = {https://juser.fz-juelich.de/record/842723},
}