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@ARTICLE{Haselier:842727,
      author       = {Haselier, Christine and Biswas, Sonia and Rösch, Sarah and
                      Thumann, Gabriele and Müller, Frank and Walter, Peter},
      title        = {{C}orrelations between specific patterns of spontaneous
                      activity and stimulation efficiency in degenerated retina},
      journal      = {PLoS one},
      volume       = {12},
      number       = {12},
      issn         = {1932-6203},
      address      = {Lawrence, Kan.},
      publisher    = {PLoS},
      reportid     = {FZJ-2018-00927},
      pages        = {e0190048 -},
      year         = {2017},
      abstract     = {Retinal prostheses that are currently used to restore
                      vision in patients suffering from retinal degeneration are
                      not adjusted to the changes occurring during the remodeling
                      process of the retina. Recent studies revealed abnormal
                      rhythmic activity in the retina of genetic mouse models of
                      retinitis pigmentosa. Here we describe this abnormal
                      activity also in a pharmacologically-induced (MNU) mouse
                      model of retinal degeneration. To investigate how this
                      abnormal activity affects the excitability of retinal
                      ganglion cells, we recorded the electrical activity from
                      whole mounted retinas of rd10 mice and MNU-treated mice
                      using a microelectrode array system and applied biphasic
                      current pulses of different amplitude and duration to
                      stimulate ganglion cells electrically. We show that the
                      electrical stimulation efficiency is strongly reduced in
                      degenerated retinas, in particular when abnormal activity
                      such as oscillations and rhythmic firing of bursts of action
                      potentials can be observed. Using a prestimulus pulse
                      sequence, we could abolish rhythmic retinal activity. Under
                      these conditions, the stimulation efficiency was enhanced in
                      a few cases but not in the majority of tested cells.
                      Nevertheless, this approach supports the idea that modified
                      stimulation protocols could help to improve the efficiency
                      of retinal prostheses in the future.},
      cin          = {ICS-4},
      ddc          = {500},
      cid          = {I:(DE-Juel1)ICS-4-20110106},
      pnm          = {553 - Physical Basis of Diseases (POF3-553)},
      pid          = {G:(DE-HGF)POF3-553},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29281713},
      UT           = {WOS:000419006200058},
      doi          = {10.1371/journal.pone.0190048},
      url          = {https://juser.fz-juelich.de/record/842727},
}