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@ARTICLE{Landmann:843663,
author = {Landmann, Julia and Richter, Franziska and Oros-Peusquens,
Ana-Maria and Shah, N. J. and Classen, Joseph and Neely, G.
Gregory and Richter, Angelika and Penninger, Josef M. and
Bechmann, Ingo},
title = {{N}euroanatomy of pain-deficiency and cross-modal
activation in calcium channel subunit ({CACN}) α2δ3
knockout mice},
journal = {Brain structure $\&$ function},
volume = {223},
number = {1},
issn = {1863-2661},
address = {Berlin},
publisher = {Springer},
reportid = {FZJ-2018-01232},
pages = {111 - 130},
year = {2018},
abstract = {The phenotype of calcium channel subunit (CACN) α2δ3
knockout (KO) mice includes sensory cross-activation and
deficient pain perception. Sensory cross-activation defines
the activation of a sensory cortical region by input from
another modality due to reorganization in the brain such as
after sensory loss. To obtain mechanistic insight into both
phenomena, we employed a comprehensive battery of
neuroanatomical techniques. While CACNα2δ3 was
ubiquitously expressed in wild-type mice, it was absent in
α2δ3 KO animals. Immunostaining of α1A, α1B, and α1E
revealed upregulation of N-type and R-type, but not P/Q-type
Cav2 channels in cortical neurons of CACNα2δ3 KO mice.
Compared to wild-type mice, axonal processes in
somatosensory cortex were enhanced, and dendritic processes
reduced, in CACNα2δ3 KO mice. Immunohistochemical and MRI
analyses, investigating morphology, thalamocortical and
intra-/intercortical trajectories, revealed a disparity
between projection and commissural fibers with reduction of
the number of spatial specificity of thalamocortical
projections. L1cam staining revealed wide-ranging
projections of thalamocortical fibers reaching both
somatosensory/motor and visual cortical areas. Activation
(c-fos+) of excitatory and inhibitory neurons suggested that
deficient pain perception in α2δ3 KO mice is unlikely to
result from cortical disinhibition. Collectively, our data
demonstrate that knock out of CACN α2δ3 results in some
structural abnormalities whose functional implications
converge to dedifferentiation of sensory activation.},
cin = {INM-4 / JARA-BRAIN},
ddc = {610},
cid = {I:(DE-Juel1)INM-4-20090406 / $I:(DE-82)080010_20140620$},
pnm = {573 - Neuroimaging (POF3-573)},
pid = {G:(DE-HGF)POF3-573},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:28733833},
UT = {WOS:000422845500010},
doi = {10.1007/s00429-017-1473-4},
url = {https://juser.fz-juelich.de/record/843663},
}