000843669 001__ 843669
000843669 005__ 20210129232628.0
000843669 0247_ $$2doi$$a10.3389/fneur.2017.00682
000843669 0247_ $$2Handle$$a2128/17392
000843669 0247_ $$2pmid$$apmid:29326646
000843669 0247_ $$2WOS$$aWOS:000418151900001
000843669 0247_ $$2altmetric$$aaltmetric:30639673
000843669 037__ $$aFZJ-2018-01238
000843669 041__ $$aEnglish
000843669 082__ $$a610
000843669 1001_ $$0P:(DE-HGF)0$$aPohl, Anna$$b0$$eCorresponding author
000843669 245__ $$aImpaired Emotional Mirroring in Parkinson’s Disease—A Study on Brain Activation during Processing of Facial Expressions
000843669 260__ $$aLausanne$$bFrontiers Research Foundation$$c2017
000843669 3367_ $$2DRIVER$$aarticle
000843669 3367_ $$2DataCite$$aOutput Types/Journal article
000843669 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1553693290_19436
000843669 3367_ $$2BibTeX$$aARTICLE
000843669 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000843669 3367_ $$00$$2EndNote$$aJournal Article
000843669 520__ $$aBackground: Affective dysfunctions are common in patients with Parkinson’s disease, but the underlying neurobiological deviations have rarely been examined. Parkinson’s disease is characterized by a loss of dopamine neurons in the substantia nigra resulting in impairment of motor and non-motor basal ganglia-cortical loops. Concerning emotional deficits, some studies provide evidence for altered brain processing in limbic- and lateral-orbitofrontal gating loops. In a second line of evidence, human premotor and inferior parietal homologs of mirror neuron areas were involved in processing and understanding of emotional facial expressions. We examined deviations in brain activation during processing of facial expressions in patients and related these to emotion recognition accuracy.Methods: 13 patients and 13 healthy controls underwent an emotion recognition task and a functional magnetic resonance imaging (fMRI) measurement. In the Emotion Hexagon test, participants were presented with blends of two emotions and had to indicate which emotion best described the presented picture. Blended pictures with three levels of difficulty were included. During fMRI scanning, participants observed video clips depicting emotional, non-emotional, and neutral facial expressions or were asked to produce these facial expressions themselves.Results: Patients performed slightly worse in the emotion recognition task, but only when judging the most ambiguous facial expressions. Both groups activated inferior frontal and anterior inferior parietal homologs of mirror neuron areas during observation and execution of the emotional facial expressions. During observation, responses in the pars opercularis of the right inferior frontal gyrus, in the bilateral inferior parietal lobule and in the bilateral supplementary motor cortex were decreased in patients. Furthermore, in patients, activation of the right anterior inferior parietal lobule was positively related to accuracy in the emotion recognition task.Conclusion: Our data provide evidence for a contribution of human homologs of monkey mirror areas to the emotion recognition deficit in Parkinson’s disease.
000843669 536__ $$0G:(DE-HGF)POF3-573$$a573 - Neuroimaging (POF3-573)$$cPOF3-573$$fPOF III$$x0
000843669 536__ $$0G:(DE-HGF)POF3-572$$a572 - (Dys-)function and Plasticity (POF3-572)$$cPOF3-572$$fPOF III$$x1
000843669 588__ $$aDataset connected to CrossRef
000843669 7001_ $$0P:(DE-HGF)0$$aAnders, Silke$$b1
000843669 7001_ $$0P:(DE-HGF)0$$aChen, Hong$$b2
000843669 7001_ $$0P:(DE-HGF)0$$aPatel, Harshal Jayeshkumar$$b3
000843669 7001_ $$0P:(DE-HGF)0$$aHeller, Julia$$b4
000843669 7001_ $$0P:(DE-Juel1)162203$$aReetz, Kathrin$$b5
000843669 7001_ $$0P:(DE-HGF)0$$aMathiak, Klaus$$b6
000843669 7001_ $$0P:(DE-Juel1)142495$$aBinkofski, Ferdinand$$b7
000843669 773__ $$0PERI:(DE-600)2564214-5$$a10.3389/fneur.2017.00682$$gVol. 8, p. 682$$p682$$tFrontiers in neurology$$v8$$x1664-2295$$y2017
000843669 8564_ $$uhttps://juser.fz-juelich.de/record/843669/files/fneur-08-00682.pdf$$yOpenAccess
000843669 8564_ $$uhttps://juser.fz-juelich.de/record/843669/files/fneur-08-00682.gif?subformat=icon$$xicon$$yOpenAccess
000843669 8564_ $$uhttps://juser.fz-juelich.de/record/843669/files/fneur-08-00682.jpg?subformat=icon-1440$$xicon-1440$$yOpenAccess
000843669 8564_ $$uhttps://juser.fz-juelich.de/record/843669/files/fneur-08-00682.jpg?subformat=icon-180$$xicon-180$$yOpenAccess
000843669 8564_ $$uhttps://juser.fz-juelich.de/record/843669/files/fneur-08-00682.jpg?subformat=icon-640$$xicon-640$$yOpenAccess
000843669 8564_ $$uhttps://juser.fz-juelich.de/record/843669/files/fneur-08-00682.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000843669 909CO $$ooai:juser.fz-juelich.de:843669$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000843669 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-HGF)0$$aForschungszentrum Jülich$$b3$$kFZJ
000843669 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)142495$$aForschungszentrum Jülich$$b7$$kFZJ
000843669 9131_ $$0G:(DE-HGF)POF3-573$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vNeuroimaging$$x0
000843669 9131_ $$0G:(DE-HGF)POF3-572$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$v(Dys-)function and Plasticity$$x1
000843669 9141_ $$y2018
000843669 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000843669 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000843669 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bFRONT NEUROL : 2015
000843669 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal
000843669 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ
000843669 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000843669 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000843669 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000843669 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000843669 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000843669 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000843669 9201_ $$0I:(DE-Juel1)INM-4-20090406$$kINM-4$$lPhysik der Medizinischen Bildgebung$$x0
000843669 9201_ $$0I:(DE-82)080010_20140620$$kJARA-BRAIN$$lJARA-BRAIN$$x1
000843669 9201_ $$0I:(DE-Juel1)INM-11-20170113$$kINM-11$$lJara-Institut Quantum Information$$x2
000843669 980__ $$ajournal
000843669 980__ $$aVDB
000843669 980__ $$aI:(DE-Juel1)INM-4-20090406
000843669 980__ $$aI:(DE-82)080010_20140620
000843669 980__ $$aI:(DE-Juel1)INM-11-20170113
000843669 980__ $$aUNRESTRICTED
000843669 9801_ $$aFullTexts