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@ARTICLE{Pohl:843669,
      author       = {Pohl, Anna and Anders, Silke and Chen, Hong and Patel,
                      Harshal Jayeshkumar and Heller, Julia and Reetz, Kathrin and
                      Mathiak, Klaus and Binkofski, Ferdinand},
      title        = {{I}mpaired {E}motional {M}irroring in {P}arkinson’s
                      {D}isease—{A} {S}tudy on {B}rain {A}ctivation during
                      {P}rocessing of {F}acial {E}xpressions},
      journal      = {Frontiers in neurology},
      volume       = {8},
      issn         = {1664-2295},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2018-01238},
      pages        = {682},
      year         = {2017},
      abstract     = {Background: Affective dysfunctions are common in patients
                      with Parkinson’s disease, but the underlying
                      neurobiological deviations have rarely been examined.
                      Parkinson’s disease is characterized by a loss of dopamine
                      neurons in the substantia nigra resulting in impairment of
                      motor and non-motor basal ganglia-cortical loops. Concerning
                      emotional deficits, some studies provide evidence for
                      altered brain processing in limbic- and
                      lateral-orbitofrontal gating loops. In a second line of
                      evidence, human premotor and inferior parietal homologs of
                      mirror neuron areas were involved in processing and
                      understanding of emotional facial expressions. We examined
                      deviations in brain activation during processing of facial
                      expressions in patients and related these to emotion
                      recognition accuracy.Methods: 13 patients and 13 healthy
                      controls underwent an emotion recognition task and a
                      functional magnetic resonance imaging (fMRI) measurement. In
                      the Emotion Hexagon test, participants were presented with
                      blends of two emotions and had to indicate which emotion
                      best described the presented picture. Blended pictures with
                      three levels of difficulty were included. During fMRI
                      scanning, participants observed video clips depicting
                      emotional, non-emotional, and neutral facial expressions or
                      were asked to produce these facial expressions
                      themselves.Results: Patients performed slightly worse in the
                      emotion recognition task, but only when judging the most
                      ambiguous facial expressions. Both groups activated inferior
                      frontal and anterior inferior parietal homologs of mirror
                      neuron areas during observation and execution of the
                      emotional facial expressions. During observation, responses
                      in the pars opercularis of the right inferior frontal gyrus,
                      in the bilateral inferior parietal lobule and in the
                      bilateral supplementary motor cortex were decreased in
                      patients. Furthermore, in patients, activation of the right
                      anterior inferior parietal lobule was positively related to
                      accuracy in the emotion recognition task.Conclusion: Our
                      data provide evidence for a contribution of human homologs
                      of monkey mirror areas to the emotion recognition deficit in
                      Parkinson’s disease.},
      cin          = {INM-4 / JARA-BRAIN / INM-11},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / $I:(DE-82)080010_20140620$ /
                      I:(DE-Juel1)INM-11-20170113},
      pnm          = {573 - Neuroimaging (POF3-573) / 572 - (Dys-)function and
                      Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-573 / G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29326646},
      UT           = {WOS:000418151900001},
      doi          = {10.3389/fneur.2017.00682},
      url          = {https://juser.fz-juelich.de/record/843669},
}