TY  - JOUR
AU  - Jacobs, Heidi
AU  - Dillen, Kim
AU  - Göreci, Yasemin
AU  - Risius, Okka
AU  - Onur, Özgür
AU  - Fink, Gereon R.
AU  - Kukolja, Juraj
TI  - Consolidation in older adults depends upon competition between resting-state networks
JO  - Frontiers in aging neuroscience
VL  - 6
SN  - 1663-4365
CY  - Lausanne
PB  - Frontiers Research Foundation
M1  - FZJ-2018-01401
SP  - 344
PY  - 2015
AB  - Memory encoding and retrieval problems are inherent to aging. To date, however, the effect of aging upon the neural correlates of forming memory traces remains poorly understood. Resting-state fMRI connectivity can be used to investigate initial consolidation. We compared within and between network connectivity differences between healthy young and older participants before encoding, after encoding and before retrieval by means of resting-state fMRI. Alterations over time in the between-network connectivity analyses correlated with retrieval performance, whereas within-network connectivity did not: a higher level of negative coupling or competition between the default mode and the executive networks during the after encoding condition was associated with increased retrieval performance in the older adults, but not in the young group. Data suggest that the effective formation of memory traces depends on an age-dependent, dynamic reorganization of the interaction between multiple, large-scale functional networks. Our findings demonstrate that a cross-network based approach can further the understanding of the neural underpinnings of aging-associated memory decline.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000348116000001
C6  - pmid:25620930
DO  - DOI:10.3389/fnagi.2014.00344
UR  - https://juser.fz-juelich.de/record/843871
ER  -