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@ARTICLE{Jacobs:843871,
author = {Jacobs, Heidi and Dillen, Kim and Göreci, Yasemin and
Risius, Okka and Onur, Özgür and Fink, Gereon R. and
Kukolja, Juraj},
title = {{C}onsolidation in older adults depends upon competition
between resting-state networks},
journal = {Frontiers in aging neuroscience},
volume = {6},
issn = {1663-4365},
address = {Lausanne},
publisher = {Frontiers Research Foundation},
reportid = {FZJ-2018-01401},
pages = {344},
year = {2015},
abstract = {Memory encoding and retrieval problems are inherent to
aging. To date, however, the effect of aging upon the neural
correlates of forming memory traces remains poorly
understood. Resting-state fMRI connectivity can be used to
investigate initial consolidation. We compared within and
between network connectivity differences between healthy
young and older participants before encoding, after encoding
and before retrieval by means of resting-state fMRI.
Alterations over time in the between-network connectivity
analyses correlated with retrieval performance, whereas
within-network connectivity did not: a higher level of
negative coupling or competition between the default mode
and the executive networks during the after encoding
condition was associated with increased retrieval
performance in the older adults, but not in the young group.
Data suggest that the effective formation of memory traces
depends on an age-dependent, dynamic reorganization of the
interaction between multiple, large-scale functional
networks. Our findings demonstrate that a cross-network
based approach can further the understanding of the neural
underpinnings of aging-associated memory decline.},
cin = {INM-3},
ddc = {610},
cid = {I:(DE-Juel1)INM-3-20090406},
pnm = {572 - (Dys-)function and Plasticity (POF3-572)},
pid = {G:(DE-HGF)POF3-572},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000348116000001},
pubmed = {pmid:25620930},
doi = {10.3389/fnagi.2014.00344},
url = {https://juser.fz-juelich.de/record/843871},
}