TY  - JOUR
AU  - Lorson, Thomas
AU  - Jaksch, Sebastian
AU  - Lübtow, Michael M.
AU  - Jüngst, Tomasz
AU  - Groll, Jürgen
AU  - Lühmann, Tessa
AU  - Luxenhofer, Robert
TI  - A Thermogelling Supramolecular Hydrogel with Sponge-Like Morphology as a Cytocompatible Bioink
JO  - Biomacromolecules
VL  - 18
IS  - 7
SN  - 1526-4602
CY  - Columbus, Ohio
PB  - American Chemical Soc.
M1  - FZJ-2018-01425
SP  - 2161 - 2171
PY  - 2017
AB  - Biocompatible polymers that form thermoreversible supramolecular hydrogels have gained great interest in biomaterials research and tissue engineering. When favorable rheological properties are achieved at the same time, they are particularly promising candidates as material that allow for the printing of cells, so-called bioinks. We synthesized a novel thermogelling block copolymer and investigated the rheological properties of its aqueous solution by viscosimetry and rheology. The polymers undergo thermogelation between room temperature and body temperature, form transparent hydrogels of surprisingly high strength (G′ > 1000 Pa) and show rapid and complete shear recovery after stress. Small angle neutron scattering suggests an unusual bicontinuous sponge-like gel network. Excellent cytocompatibility was demonstrated with NIH 3T3 fibroblasts, which were incorporated and bioplotted into predefined 3D hydrogel structures without significant loss of viability. The developed materials fulfill all criteria for future use as bioink for biofabrication.
LB  - PUB:(DE-HGF)16
C6  - pmid:28653854
UR  - <Go to ISI:>//WOS:000405444900015
DO  - DOI:10.1021/acs.biomac.7b00481
UR  - https://juser.fz-juelich.de/record/843898
ER  -