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@ARTICLE{Bludau:843922,
      author       = {Bludau, Sebastian and Mühleisen, Thomas W. and Eickhoff,
                      Simon and Hawrylycz, Michael J. and Cichon, Sven and Amunts,
                      Katrin},
      title        = {{I}ntegration of transcriptomic and cytoarchitectonic data
                      implicates a role for {MAOA} and {TAC}1 in the
                      limbic-cortical network},
      journal      = {Brain structure $\&$ function},
      volume       = {223},
      number       = {5},
      issn         = {1863-2661},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {FZJ-2018-01446},
      pages        = {2335–2342},
      year         = {2018},
      abstract     = {Decoding the chain from genes to cognition requires
                      detailed insights how areas with specific gene activities
                      and microanatomical architectures contribute to brain
                      function and dysfunction. The Allen Human Brain Atlas
                      contains regional gene expression data, while the JuBrain
                      Atlas offers three-dimensional cytoarchitectonic maps
                      reflecting interindividual variability. To date, an
                      integrated framework that combines the analytical benefits
                      of both scientific platforms towards a multi-level brain
                      atlas of adult humans was not available. We have, therefore,
                      developed JuGEx, a new method for integrating tissue
                      transcriptome and cytoarchitectonic segregation. We
                      investigated differential gene expression in two JuBrain
                      areas of the frontal pole that we have structurally and
                      functionally characterized in previous studies. Our results
                      show a significant upregulation of MAOA and TAC1 in the
                      medial area frontopolaris which is a node in the
                      limbic-cortical network and known to be susceptible for gray
                      matter loss and behavioral dysfunction in patients with
                      depression. The MAOA gene encodes an enzyme which is
                      involved in the catabolism of dopamine, norepinephrine,
                      serotonin, and other monoaminergic neurotransmitters. The
                      TAC1 locus generates hormones that play a role in neuron
                      excitations and behavioral responses. Overall, JuGEx
                      provides a new tool for the scientific community that
                      empowers research from basic, cognitive and clinical
                      neuroscience in brain regions and disease models with regard
                      to gene expression.},
      cin          = {INM-1 / INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-7-20090406},
      pnm          = {574 - Theory, modelling and simulation (POF3-574) / HBP
                      SGA1 - Human Brain Project Specific Grant Agreement 1
                      (720270)},
      pid          = {G:(DE-HGF)POF3-574 / G:(EU-Grant)720270},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29478144},
      UT           = {WOS:000433110800018},
      doi          = {10.1007/s00429-018-1620-6},
      url          = {https://juser.fz-juelich.de/record/843922},
}