%0 Journal Article
%A Milić, Dalibor
%A Dick, Markus
%A Mulnaes, Daniel
%A Pfleger, Christopher
%A Kinnen, Anna
%A Gohlke, Holger
%A Groth, Georg
%T Recognition motif and mechanism of ripening inhibitory peptides in plant hormone receptor ETR1
%J Scientific reports
%V 8
%N 1
%@ 2045-2322
%C London
%I Nature Publishing Group
%M FZJ-2018-01583
%P 3890
%D 2018
%X Synthetic peptides derived from ethylene-insensitive protein 2 (EIN2), a central regulator of ethylene signalling, were recently shown to delay fruit ripening by interrupting protein–protein interactions in the ethylene signalling pathway. Here, we show that the inhibitory peptide NOP-1 binds to the GAF domain of ETR1 – the prototype of the plant ethylene receptor family. Site-directed mutagenesis and computational studies reveal the peptide interaction site and a plausible molecular mechanism for the ripening inhibition.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29497085
%U <Go to ISI:>//WOS:000426354200062
%R 10.1038/s41598-018-21952-3
%U https://juser.fz-juelich.de/record/844074