TY  - JOUR
AU  - Milić, Dalibor
AU  - Dick, Markus
AU  - Mulnaes, Daniel
AU  - Pfleger, Christopher
AU  - Kinnen, Anna
AU  - Gohlke, Holger
AU  - Groth, Georg
TI  - Recognition motif and mechanism of ripening inhibitory peptides in plant hormone receptor ETR1
JO  - Scientific reports
VL  - 8
IS  - 1
SN  - 2045-2322
CY  - London
PB  - Nature Publishing Group
M1  - FZJ-2018-01583
SP  - 3890
PY  - 2018
AB  - Synthetic peptides derived from ethylene-insensitive protein 2 (EIN2), a central regulator of ethylene signalling, were recently shown to delay fruit ripening by interrupting protein–protein interactions in the ethylene signalling pathway. Here, we show that the inhibitory peptide NOP-1 binds to the GAF domain of ETR1 – the prototype of the plant ethylene receptor family. Site-directed mutagenesis and computational studies reveal the peptide interaction site and a plausible molecular mechanism for the ripening inhibition.
LB  - PUB:(DE-HGF)16
C6  - pmid:29497085
UR  - <Go to ISI:>//WOS:000426354200062
DO  - DOI:10.1038/s41598-018-21952-3
UR  - https://juser.fz-juelich.de/record/844074
ER  -