% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{daSilva:844225,
      author       = {da Silva, N. A. and Lohmann, P. and Fairney, J. and Magill,
                      A. W. and Oros Peusquens, A.-M. and Choi, C.-H. and
                      Stirnberg, R. and Stoffels, G. and Galldiks, N. and Golay,
                      X. and Langen, K.-J. and Shah, N. J.},
      title        = {{H}ybrid {MR}-{PET} of brain tumours using amino acid {PET}
                      and chemical exchange saturation transfer {MRI}},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {45},
      number       = {6},
      issn         = {1619-7089},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {FZJ-2018-01666},
      pages        = {1031–1040},
      year         = {2018},
      abstract     = {PurposePET using radiolabelled amino acids has become a
                      promising tool in the diagnostics of gliomas and brain
                      metastasis. Current research is focused on the evaluation of
                      amide proton transfer (APT) chemical exchange saturation
                      transfer (CEST) MR imaging for brain tumour imaging. In this
                      hybrid MR-PET study, brain tumours were compared using 3D
                      data derived from APT-CEST MRI and amino acid PET using
                      O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET).MethodsEight
                      patients with gliomas were investigated simultaneously with
                      18F-FET PET and APT-CEST MRI using a 3-T MR-BrainPET
                      scanner. CEST imaging was based on a steady-state approach
                      using a B1 average power of 1μT. B0 field inhomogeneities
                      were corrected a Prametric images of magnetisation transfer
                      ratio asymmetry (MTRasym) and differences to the
                      extrapolated semi-solid magnetisation transfer reference
                      method, APT# and nuclear Overhauser effect (NOE#), were
                      calculated. Statistical analysis of the tumour-to-brain
                      ratio of the CEST data was performed against PET data using
                      the non-parametric Wilcoxon test.ResultsA tumour-to-brain
                      ratio derived from APT# and 18F-FET presented no significant
                      differences, and no correlation was found between APT# and
                      18F-FET PET data. The distance between local hot spot APT#
                      and 18F-FET were different (average 20 ± 13 mm, range
                      4–45 mm).ConclusionFor the first time, CEST images were
                      compared with 18F-FET in a simultaneous MR-PET measurement.
                      Imaging findings derived from18F-FET PET and APT CEST MRI
                      seem to provide different biological information. The
                      validation of these imaging findings by histological
                      confirmation is necessary, ideally using stereotactic
                      biopsy.},
      cin          = {INM-3 / INM-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29478081},
      UT           = {WOS:000430832400016},
      doi          = {10.1007/s00259-018-3940-4},
      url          = {https://juser.fz-juelich.de/record/844225},
}