000844237 001__ 844237
000844237 005__ 20210129232832.0
000844237 0247_ $$2doi$$a10.1007/s00429-018-1616-2
000844237 0247_ $$2ISSN$$a0340-2061
000844237 0247_ $$2ISSN$$a1432-0568
000844237 0247_ $$2ISSN$$a1863-2653
000844237 0247_ $$2ISSN$$a1863-2661
000844237 0247_ $$2pmid$$apmid:29374792
000844237 0247_ $$2WOS$$aWOS:000433110800003
000844237 037__ $$aFZJ-2018-01678
000844237 082__ $$a610
000844237 1001_ $$0P:(DE-Juel1)169149$$aTrempler, Ima$$b0$$eCorresponding author
000844237 245__ $$aAssociation of grey matter changes with stability and flexibility of prediction in akinetic-rigid Parkinson’s disease
000844237 260__ $$aBerlin$$bSpringer$$c2018
000844237 3367_ $$2DRIVER$$aarticle
000844237 3367_ $$2DataCite$$aOutput Types/Journal article
000844237 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1530271083_14343
000844237 3367_ $$2BibTeX$$aARTICLE
000844237 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000844237 3367_ $$00$$2EndNote$$aJournal Article
000844237 520__ $$aParkinson’s disease (PD), which is caused by degeneration of dopaminergic neurons in the midbrain, results in a heterogeneous clinical picture including cognitive decline. Since the phasic signal of dopamine neurons is proposed to guide learning by signifying mismatches between subjects’ expectations and external events, we here investigated whether akinetic-rigid PD patients without mild cognitive impairment exhibit difficulties in dealing with either relevant (requiring flexibility) or irrelevant (requiring stability) prediction errors. Following our previous study on flexibility and stability in prediction (Trempler et al. J Cogn Neurosci 29(2):298–309, 2017), we then assessed whether deficits would correspond with specific structural alterations in dopaminergic regions as well as in inferior frontal cortex, medial prefrontal cortex, and the hippocampus. Twenty-one healthy controls and twenty-one akinetic-rigid PD patients on and off medication performed a task which required to serially predict upcoming items. Switches between predictable sequences had to be indicated via button press, whereas sequence omissions had to be ignored. Independent of the disease, midbrain volume was related to a general response bias to unexpected events, whereas right putamen volume correlated with the ability to discriminate between relevant and irrelevant prediction errors. However, patients compared with healthy participants showed deficits in stabilisation against irrelevant prediction errors, associated with thickness of right inferior frontal gyrus and left medial prefrontal cortex. Flexible updating due to relevant prediction errors was also affected in patients compared with controls and associated with right hippocampus volume. 
000844237 536__ $$0G:(DE-HGF)POF3-572$$a572 - (Dys-)function and Plasticity (POF3-572)$$cPOF3-572$$fPOF III$$x0
000844237 588__ $$aDataset connected to CrossRef
000844237 7001_ $$0P:(DE-Juel1)131716$$aBinder, Ellen$$b1
000844237 7001_ $$0P:(DE-HGF)0$$aEl-Sourani, Nadiya$$b2
000844237 7001_ $$0P:(DE-HGF)0$$aSchiffler, Patrick$$b3
000844237 7001_ $$0P:(DE-HGF)0$$aTenberge, Jan-Gerd$$b4
000844237 7001_ $$0P:(DE-HGF)0$$aSchiffer, Anne-Marike$$b5
000844237 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b6
000844237 7001_ $$0P:(DE-HGF)0$$aSchubotz, Ricarda I.$$b7
000844237 773__ $$0PERI:(DE-600)2303775-1$$a10.1007/s00429-018-1616-2$$n5$$p2097–2111 $$tBrain structure & function$$v223$$x1863-2661$$y2018
000844237 8564_ $$uhttps://juser.fz-juelich.de/record/844237/files/Trempler2018_Article_AssociationOfGreyMatterChanges.pdf$$yRestricted
000844237 8564_ $$uhttps://juser.fz-juelich.de/record/844237/files/Trempler2018_Article_AssociationOfGreyMatterChanges.pdf?subformat=pdfa$$xpdfa$$yRestricted
000844237 8564_ $$uhttps://juser.fz-juelich.de/record/844237/files/Trempler2018_Article_AssociationOfGreyMatterChanges.gif?subformat=icon$$xicon$$yRestricted
000844237 8564_ $$uhttps://juser.fz-juelich.de/record/844237/files/Trempler2018_Article_AssociationOfGreyMatterChanges.jpg?subformat=icon-1440$$xicon-1440$$yRestricted
000844237 8564_ $$uhttps://juser.fz-juelich.de/record/844237/files/Trempler2018_Article_AssociationOfGreyMatterChanges.jpg?subformat=icon-180$$xicon-180$$yRestricted
000844237 8564_ $$uhttps://juser.fz-juelich.de/record/844237/files/Trempler2018_Article_AssociationOfGreyMatterChanges.jpg?subformat=icon-640$$xicon-640$$yRestricted
000844237 909CO $$ooai:juser.fz-juelich.de:844237$$pVDB
000844237 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)169149$$aForschungszentrum Jülich$$b0$$kFZJ
000844237 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131716$$aForschungszentrum Jülich$$b1$$kFZJ
000844237 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)131716$$a INM-3$$b1
000844237 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131720$$aForschungszentrum Jülich$$b6$$kFZJ
000844237 9131_ $$0G:(DE-HGF)POF3-572$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$v(Dys-)function and Plasticity$$x0
000844237 9141_ $$y2018
000844237 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000844237 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000844237 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000844237 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000844237 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000844237 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bBRAIN STRUCT FUNCT : 2015
000844237 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000844237 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000844237 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000844237 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000844237 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000844237 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record
000844237 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000844237 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bBRAIN STRUCT FUNCT : 2015
000844237 920__ $$lyes
000844237 9201_ $$0I:(DE-Juel1)INM-3-20090406$$kINM-3$$lKognitive Neurowissenschaften$$x0
000844237 980__ $$ajournal
000844237 980__ $$aVDB
000844237 980__ $$aI:(DE-Juel1)INM-3-20090406
000844237 980__ $$aUNRESTRICTED