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@ARTICLE{Trempler:844237,
      author       = {Trempler, Ima and Binder, Ellen and El-Sourani, Nadiya and
                      Schiffler, Patrick and Tenberge, Jan-Gerd and Schiffer,
                      Anne-Marike and Fink, Gereon R. and Schubotz, Ricarda I.},
      title        = {{A}ssociation of grey matter changes with stability and
                      flexibility of prediction in akinetic-rigid {P}arkinson’s
                      disease},
      journal      = {Brain structure $\&$ function},
      volume       = {223},
      number       = {5},
      issn         = {1863-2661},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {FZJ-2018-01678},
      pages        = {2097–2111},
      year         = {2018},
      abstract     = {Parkinson’s disease (PD), which is caused by degeneration
                      of dopaminergic neurons in the midbrain, results in a
                      heterogeneous clinical picture including cognitive decline.
                      Since the phasic signal of dopamine neurons is proposed to
                      guide learning by signifying mismatches between subjects’
                      expectations and external events, we here investigated
                      whether akinetic-rigid PD patients without mild cognitive
                      impairment exhibit difficulties in dealing with either
                      relevant (requiring flexibility) or irrelevant (requiring
                      stability) prediction errors. Following our previous study
                      on flexibility and stability in prediction (Trempler et al.
                      J Cogn Neurosci 29(2):298–309, 2017), we then assessed
                      whether deficits would correspond with specific structural
                      alterations in dopaminergic regions as well as in inferior
                      frontal cortex, medial prefrontal cortex, and the
                      hippocampus. Twenty-one healthy controls and twenty-one
                      akinetic-rigid PD patients on and off medication performed a
                      task which required to serially predict upcoming items.
                      Switches between predictable sequences had to be indicated
                      via button press, whereas sequence omissions had to be
                      ignored. Independent of the disease, midbrain volume was
                      related to a general response bias to unexpected events,
                      whereas right putamen volume correlated with the ability to
                      discriminate between relevant and irrelevant prediction
                      errors. However, patients compared with healthy participants
                      showed deficits in stabilisation against irrelevant
                      prediction errors, associated with thickness of right
                      inferior frontal gyrus and left medial prefrontal cortex.
                      Flexible updating due to relevant prediction errors was also
                      affected in patients compared with controls and associated
                      with right hippocampus volume.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29374792},
      UT           = {WOS:000433110800003},
      doi          = {10.1007/s00429-018-1616-2},
      url          = {https://juser.fz-juelich.de/record/844237},
}