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@ARTICLE{Lucio:844248,
      author       = {Lucio, David and Martínez-Ohárriz, María Cristina and
                      González-Navarro, Carlos J. and Navarro-Herrera, David and
                      González-Gaitano, Gustavo and Radulescu, Aurel and Irache,
                      Juan M.},
      title        = {{C}oencapsulation of cyclodextrins into poly(anhydride)
                      nanoparticles to improve the oral administration of
                      glibenclamide. {A} screening on {C}. elegans},
      journal      = {Colloids and surfaces / B},
      volume       = {163},
      issn         = {0927-7765},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2018-01689},
      pages        = {64 - 72},
      year         = {2018},
      abstract     = {This work describes the feasibility of poly(anhydride)
                      nanoparticles as carriers for the oral administration of
                      glibenclamide (GB) as well as the in vivo evaluation of
                      their hypolipidemic effect in a C. elegans model. For this
                      purpose, and in order to increase the GB payload, the drug
                      was encapsulated in nanoparticles in presence of
                      cyclodextrins (either βCD or HPβCD). The optimized
                      nanoparticles displayed a size of about 220 nm and a
                      negative zeta potential (−40 mV), with a drug loading up
                      to 52 μg/mg. Small-angle neutron scattering studies
                      suggested an internal fractal-like structure, based on the
                      repetition of spherical blocks of polymeric units (about
                      5 nm) grouped to form the nanoparticle. X-ray diffraction
                      study confirmed the absence of crystalline GB molecules due
                      to its dispersion into the nanoparticles, either entrapped
                      in the polymer chains and/or included into cyclodextrin
                      cavities. GB-loaded nanoparticles induced a significant
                      reduction in the fat content of C. elegans. This
                      hypolipidemic effect was slightly higher for the
                      nanoparticles prepared with coencapsulated HPβCD $(8.2\%)$
                      than for those prepared with βCD $(7.9\%)$ or in the
                      absence of cyclodextrins $(7.0\%).$ In summary, the
                      coencapsulation of cyclodextrins into poly(anhydride)
                      nanoparticles could be an interesting strategy to develop
                      new oral formulations of glibenclamide.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
                      Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29277019},
      UT           = {WOS:000427217300008},
      doi          = {10.1016/j.colsurfb.2017.12.038},
      url          = {https://juser.fz-juelich.de/record/844248},
}