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@ARTICLE{Michely:844288,
      author       = {Michely, J. and Volz, L. J. and Hoffstaedter, F. and
                      Tittgemeyer, M. and Eickhoff, Simon and Fink, G. R. and
                      Grefkes, C.},
      title        = {{N}etwork connectivity of motor control in the ageing
                      brain},
      journal      = {NeuroImage: Clinical},
      volume       = {18},
      issn         = {2213-1582},
      address      = {[Amsterdam u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2018-01728},
      pages        = {443 - 455},
      year         = {2018},
      abstract     = {Older individuals typically display stronger regional brain
                      activity than younger subjects during motor performance.
                      However, knowledge regarding age-related changes of motor
                      network interactions between brain regions remains scarce.
                      We here investigated the impact of ageing on the interaction
                      of cortical areas during movement selection and initiation
                      using dynamic causal modelling (DCM). We found that
                      age-related psychomotor slowing was accompanied by increases
                      in both regional activity and effective connectivity,
                      especially for ‘core’ motor coupling targeting primary
                      motor cortex (M1). Interestingly, younger participants
                      within the older group showed strongest connectivity
                      targeting M1, which steadily decreased with advancing age.
                      Conversely, prefrontal influences on the motor system
                      increased with advancing age, and were inversely correlated
                      with reduced parietal influences and core motor coupling.
                      Interestingly, higher net coupling within the
                      prefrontal-premotor-M1 axis predicted faster psychomotor
                      speed in ageing. Hence, as opposed to a uniform age-related
                      decline, our findings are compatible with the idea of
                      different age-related compensatory mechanisms, with an
                      important role of the prefrontal cortex compensating for
                      reduced coupling within the core motor network.},
      cin          = {INM-3 / INM-1 / INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-1-20090406 /
                      I:(DE-Juel1)INM-7-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29552486},
      UT           = {WOS:000433169000045},
      doi          = {10.1016/j.nicl.2018.02.001},
      url          = {https://juser.fz-juelich.de/record/844288},
}