000844306 001__ 844306
000844306 005__ 20210129232855.0
000844306 0247_ $$2doi$$a10.1002/1873-3468.12983
000844306 0247_ $$2ISSN$$a0014-5793
000844306 0247_ $$2ISSN$$a1873-3468
000844306 0247_ $$2pmid$$apmid:29360176
000844306 0247_ $$2WOS$$aWOS:000426183900006
000844306 037__ $$aFZJ-2018-01739
000844306 082__ $$a570
000844306 1001_ $$0P:(DE-Juel1)162310$$aKulawik, Andreas$$b0$$ufzj
000844306 245__ $$aAdvancements of the sFIDA method for oligomer-based diagnostics of neurodegenerative diseases
000844306 260__ $$aChichester$$bWiley$$c2018
000844306 3367_ $$2DRIVER$$aarticle
000844306 3367_ $$2DataCite$$aOutput Types/Journal article
000844306 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1520603448_31515
000844306 3367_ $$2BibTeX$$aARTICLE
000844306 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000844306 3367_ $$00$$2EndNote$$aJournal Article
000844306 520__ $$aEarly diagnosis of Alzheimer's disease (AD) is of great importance for the development of therapeutics and their application in the clinical environment. Amyloid β (Aβ) oligomers are crucial for the onset and progression of AD and represent a popular drug target, being presumably the most direct biomarker. Efforts to measure Aβ oligomers in body fluids are hampered by the low analyte concentration and presence of Aβ monomers. The surface-based fluorescence intensity distribution analysis (sFIDA) features both highly specific and sensitive oligomer quantitation as well as total insensitivity towards monomers. In this Review, we highlight structural features of oligomeric and fibrillar Aβ. Recent advancements in sFIDA assay development have been the successful automation, adaption for additional biomarkers such as α-synuclein oligomers, and significant improvement of essential assay parameters.
000844306 536__ $$0G:(DE-HGF)POF3-553$$a553 - Physical Basis of Diseases (POF3-553)$$cPOF3-553$$fPOF III$$x0
000844306 588__ $$aDataset connected to CrossRef
000844306 7001_ $$0P:(DE-Juel1)132002$$aHeise, Henrike$$b1$$ufzj
000844306 7001_ $$0P:(DE-Juel1)162137$$aZafiu, Christian$$b2$$ufzj
000844306 7001_ $$0P:(DE-Juel1)132029$$aWillbold, Dieter$$b3$$ufzj
000844306 7001_ $$0P:(DE-Juel1)157832$$aBannach, Oliver$$b4$$eCorresponding author$$ufzj
000844306 773__ $$0PERI:(DE-600)1460391-3$$a10.1002/1873-3468.12983$$gVol. 592, no. 4, p. 516 - 534$$n4$$p516 - 534$$tFEBS letters$$v592$$x0014-5793$$y2018
000844306 8564_ $$uhttps://juser.fz-juelich.de/record/844306/files/Kulawik_et_al-2018-FEBS_Letters.pdf$$yRestricted
000844306 8564_ $$uhttps://juser.fz-juelich.de/record/844306/files/Kulawik_et_al-2018-FEBS_Letters.gif?subformat=icon$$xicon$$yRestricted
000844306 8564_ $$uhttps://juser.fz-juelich.de/record/844306/files/Kulawik_et_al-2018-FEBS_Letters.jpg?subformat=icon-1440$$xicon-1440$$yRestricted
000844306 8564_ $$uhttps://juser.fz-juelich.de/record/844306/files/Kulawik_et_al-2018-FEBS_Letters.jpg?subformat=icon-180$$xicon-180$$yRestricted
000844306 8564_ $$uhttps://juser.fz-juelich.de/record/844306/files/Kulawik_et_al-2018-FEBS_Letters.jpg?subformat=icon-640$$xicon-640$$yRestricted
000844306 8564_ $$uhttps://juser.fz-juelich.de/record/844306/files/Kulawik_et_al-2018-FEBS_Letters.pdf?subformat=pdfa$$xpdfa$$yRestricted
000844306 909CO $$ooai:juser.fz-juelich.de:844306$$pVDB
000844306 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)162310$$aForschungszentrum Jülich$$b0$$kFZJ
000844306 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)132002$$aForschungszentrum Jülich$$b1$$kFZJ
000844306 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)162137$$aForschungszentrum Jülich$$b2$$kFZJ
000844306 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)132029$$aForschungszentrum Jülich$$b3$$kFZJ
000844306 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)157832$$aForschungszentrum Jülich$$b4$$kFZJ
000844306 9131_ $$0G:(DE-HGF)POF3-553$$1G:(DE-HGF)POF3-550$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lBioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences$$vPhysical Basis of Diseases$$x0
000844306 9141_ $$y2018
000844306 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000844306 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000844306 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bFEBS LETT : 2015
000844306 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000844306 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000844306 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000844306 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000844306 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000844306 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000844306 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000844306 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000844306 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000844306 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000844306 920__ $$lyes
000844306 9201_ $$0I:(DE-Juel1)ICS-6-20110106$$kICS-6$$lStrukturbiochemie $$x0
000844306 980__ $$ajournal
000844306 980__ $$aVDB
000844306 980__ $$aI:(DE-Juel1)ICS-6-20110106
000844306 980__ $$aUNRESTRICTED
000844306 981__ $$aI:(DE-Juel1)IBI-7-20200312