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@ARTICLE{Kulawik:844306,
      author       = {Kulawik, Andreas and Heise, Henrike and Zafiu, Christian
                      and Willbold, Dieter and Bannach, Oliver},
      title        = {{A}dvancements of the s{FIDA} method for oligomer-based
                      diagnostics of neurodegenerative diseases},
      journal      = {FEBS letters},
      volume       = {592},
      number       = {4},
      issn         = {0014-5793},
      address      = {Chichester},
      publisher    = {Wiley},
      reportid     = {FZJ-2018-01739},
      pages        = {516 - 534},
      year         = {2018},
      abstract     = {Early diagnosis of Alzheimer's disease (AD) is of great
                      importance for the development of therapeutics and their
                      application in the clinical environment. Amyloid β (Aβ)
                      oligomers are crucial for the onset and progression of AD
                      and represent a popular drug target, being presumably the
                      most direct biomarker. Efforts to measure Aβ oligomers in
                      body fluids are hampered by the low analyte concentration
                      and presence of Aβ monomers. The surface-based fluorescence
                      intensity distribution analysis (sFIDA) features both highly
                      specific and sensitive oligomer quantitation as well as
                      total insensitivity towards monomers. In this Review, we
                      highlight structural features of oligomeric and fibrillar
                      Aβ. Recent advancements in sFIDA assay development have
                      been the successful automation, adaption for additional
                      biomarkers such as α-synuclein oligomers, and significant
                      improvement of essential assay parameters.},
      cin          = {ICS-6},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {553 - Physical Basis of Diseases (POF3-553)},
      pid          = {G:(DE-HGF)POF3-553},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29360176},
      UT           = {WOS:000426183900006},
      doi          = {10.1002/1873-3468.12983},
      url          = {https://juser.fz-juelich.de/record/844306},
}