%0 Journal Article
%A Tavabi, Amir Hossein
%A Beleggia, Marco
%A Migunov, Vadim
%A Savenko, Alexey
%A Öktem, Ozan
%A Dunin-Borkowski, Rafal
%A Pozzi, Giulio
%T Tunable Ampere phase plate for low dose imaging of biomolecular complexes
%J Scientific reports
%V 8
%N 1
%@ 2045-2322
%C London
%I Nature Publishing Group
%M FZJ-2018-01952
%P 5592
%D 2018
%X A novel device that can be used as a tunable support-free phase plate for transmission electron microscopy of weakly scattering specimens is described. The device relies on the generation of a controlled phase shift by the magnetic field of a segment of current-carrying wire that is oriented parallel or antiparallel to the electron beam. The validity of the concept is established using both experimental electron holographic measurements and a theoretical model based on Ampere’s law. Computer simulations are used to illustrate the resulting contrast enhancement for studies of biological cells and macromolecules.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29618785
%U <Go to ISI:>//WOS:000429095600001
%R 10.1038/s41598-018-23100-3
%U https://juser.fz-juelich.de/record/844545